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Literature summary for 7.6.2.2 extracted from

  • Yang, N.; Driessen, A.J.
    The saci_2123 gene of the hyperthermoacidophile Sulfolobus acidocaldarius encodes an ATP-binding cassette multidrug transporter (2015), Extremophiles, 19, 101-108.
    View publication on PubMed
Search for more literature for 7.6.2.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic/in Sulfolobus acidocaldarius
-
 ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in Sulfolobus acidocaldarius MR31
-
 ADP + phosphate + xenobiotic/out
-
 ?

Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius
-
-
-
Sulfolobus acidocaldarius MR31
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + xenobiotic/in
-
 Sulfolobus acidocaldarius ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in
-
 Sulfolobus acidocaldarius MR31 ADP + phosphate + xenobiotic/out
-
 ?

Synonyms

Synonyms Comment Organism
multidrug resistance transporter 1
-
 Sulfolobus acidocaldarius
Smr1
-
 Sulfolobus acidocaldarius

General Information

General Information Comment Organism
malfunction compared to the wild type strain, a deletion mutant of the enzyme is more vulnerable to detergents such as SDS and cholate, antibiotics such as tetracycline, oxytetracycline, chloramphenicol and minocycline, uncouplers including carbonyl cyanide 3-chlorophenylhydrazone and 2,4-dinitrophenol, membrane-permeable compounds such as tetraphenylphosphonium ion, heterocyclic dyes such as rhodamine 6G and acridine orange, DNA intercalating dyes such as ethidium bromide, and several other chemicals Sulfolobus acidocaldarius