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Literature summary for 7.6.2.2 extracted from

  • Boncoeur, E.; Durmort, C.; Bernay, B.; Ebel, C.; Di Guilmi, A.M.; Croize, J.; Vernet, T.; Jault, J.M.
    PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones (2012), Biochemistry, 51, 7755-7765.
    View publication on PubMed
Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
orthovanadate
-
 Streptococcus pneumoniae
reserpine
-
 Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + ethidium bromide/in
-
 Streptococcus pneumoniae ADP + phosphate + ethidium bromide/out
-
 ?
ATP + H2O + fluoroquinolone/in
-
 Streptococcus pneumoniae ADP + phosphate + fluoroquinolone/out
-
 ?
ATP + H2O + Hoechst 33342/in
-
 Streptococcus pneumoniae ADP + phosphate + Hoechst 33342/out
-
 ?

Subunits

Subunits Comment Organism
heterodimer subunits PatA and PatB need to interact together to make a functional drug efflux transporter and work only as heterodimers Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
PatA/PatB
-
 Streptococcus pneumoniae