Literature summary for 7.6.2.2 extracted from

Luo, S.; Pal, D.; Shah, S.J.; Kwatra, D.; Paturi, K.D.; Mitra, A.K.
Effect of HEPES buffer on the uptake and transport of P-glycoprotein substrates and large neutral amino acids (2010), Mol. Pharm., 7, 412-420.

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Inhibitors

Inhibitors	Comment	Organism	Structure
HEPES	uptake of P-glycoprotein substrates is substantially diminished when the HEPES concentration is raised to 25 mM. Addition of 15 or 25 mM HEPES in the uptake buffer results in significant reduction in the accumulation of P-glycoprotein substrates cyclosporine-A, ritonavir, and lopinavir. Bidirectional A-B and B-A transport studies show that permeability ratio in the presence of 25 mM HEPES is significantly higher than control. HEPES stimulates the production of ATP and modulates the energy dependent efflux and uptake processes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
MDCK-MDR1 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)