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Literature summary for 7.6.2.2 extracted from

  • Nervi, P.; Li-Blatter, X.; Aanismaa, P.; Seelig, A.
    P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity (2010), Biochim. Biophys. Acta, 1798, 515-525.
    View publication on PubMed
Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in mouse embryo fibroblast Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08183
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + C12E08/in
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 Homo sapiens ADP + phosphate + C12E08/out
-
 ?
ATP + H2O + daunorubicin/in
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 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
ATP + H2O + diltiazem/in
-
 Homo sapiens ADP + phosphate + diltiazem/out
-
 ?
ATP + H2O + Triton X-100/in above the critical micellar concentration, Triton X-100 leads to a rapid and irreversible decrease in extracellular acidification rate in both, wild-type and transfected cells which is due to cell lysis Homo sapiens ADP + phosphate + Triton X-100/out
-
 ?
ATP + H2O + Tween 80/in
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 Homo sapiens ADP + phosphate + Tween 80/out
-
 ?
ATP + H2O + verapamil/in
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 Homo sapiens ADP + phosphate + verapamil/out
-
 ?
additional information tested compounds exhibiting similar influx as efflux induce different ATPase activity profiles in cells and inside-out vesicles. Their concentration is significantly lower in the cytosolic leaflet of cells than in the cytosolic leaflet of inside-out membrane vesicles, indicating that P-glycoprotein can cope with passive influx. P-glycoprotein thus transports all compounds tested at a rate proportional to ATP hydrolysis. However, it prevents substrate entry into the cytosol only if passive influx of substrates across the lipid bilayer is in a similar range as active efflux Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
MDR1
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 Homo sapiens