Literature summary for 7.6.2.2 extracted from

Jutabha, P.; Wempe, M.F.; Anzai, N.; Otomo, J.; Kadota, T.; Endou, H.
Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux (2010), Pharmacol. Res., 61, 76-84.

Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Xenopus laevis oocytes	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
doxorubicin	cis-inhibition without trans-inhibition on MDR1-mediated vinblastine efflux of Xenopus laevis oocytes expressing human P-glycoprotein	Homo sapiens
quinidine	trans-inhibition on MDR1-mediated vinblastine and digoxin efflux of Xenopus laevis oocytes expressing human P-glycoprotein	Homo sapiens
verapamil	trans-inhibition on MDR1-mediated vinblastine and digoxin efflux of Xenopus laevis oocytes expressing human P-glycoprotein	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.1455	-	vinblastine/in	25°C, pH 7.5, vinblastine efflux by MDR1-expressing oocytes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + digoxin/in	-	Homo sapiens	ADP + phosphate + digoxin/out	-	?
ATP + H2O + vinblastine/in	-	Homo sapiens	ADP + phosphate + vinblastine/out	-	?

Synonyms

Synonyms	Comment	Organism
MDR1	-	Homo sapiens
P-glycoprotein	-	Homo sapiens
P-gp	-	Homo sapiens

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Release 2023.1 (January 2023)