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Literature summary for 7.6.2.2 extracted from
- Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals (2010), Pharmacol. Res., 61, 259-263.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | rosemary phytochemicals, such as carnosic acid, have inhibitory effects on anticancer drug efflux transporter P-glycoprotein and may become useful to enhance the efficacy of cancer chemotherapy | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carnosic acid | increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated | Homo sapiens |  |
| carnosol | increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated | Homo sapiens | |
| ursolic acid | increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| KB-C2 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + daunorubicin/in | - |
Homo sapiens | ADP + phosphate + daunorubicin/out | - |
? | |
| ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB1 | - |
Homo sapiens |
| MDR1 | - |
Homo sapiens |
| P-glycoprotein | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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