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Literature summary for 7.6.2.2 extracted from

  • Arnaud, O.; Koubeissi, A.; Ettouati, L.; Terreux, R.; Alame?, G.; Grenot, C.; Dumontet, C.; Di Pietro, A.; Paris, J.; Falson, P.
    Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein (2010), J. Med. Chem., 53, 6720-6729.
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
tert-butyl (4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)-L-prolyl-N6-[(benzyloxy)carbonyl]-L-lysinate noncompetitive inhibitor towards daunorubicin and Hoechst 33342 Homo sapiens
tert-butyl (4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)-L-prolyl-N6-[(benzyloxy)carbonyl]-L-lysinate noncompetitive inhibitor towards daunorubicin and Hoechst 33342 Mus musculus
tetrandrine
-
 Homo sapiens
tetrandrine
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
K-562/R7 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + daunorubicin/in
-
 Mus musculus ADP + phosphate + daunorubicin/out
-
 ?
ATP + H2O + daunorubicin/in
-
 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
ATP + H2O + Hoechst 33342/in
-
 Mus musculus ADP + phosphate + Hoechst 33342/out
-
 ?
ATP + H2O + Hoechst 33342/in
-
 Homo sapiens ADP + phosphate + Hoechst 33342/out
-
 ?

Synonyms

Synonyms Comment Organism
P-glycoprotein
-
 Mus musculus
P-glycoprotein
-
 Homo sapiens
P-gp ABC transporter
-
 Mus musculus
P-gp ABC transporter
-
 Homo sapiens