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Literature summary for 7.6.2.2 extracted from

  • Holmstock, N.; Mols, R.; Annaert, P.; Augustijns, P.
    In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal P-glycoprotein by ritonavir causing increased darunavir absorption (2010), Drug Metab. Dispos., 38, 1407-1410.
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporine D
-
 Mus musculus
N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide
-
 Mus musculus
ritonavir inhibition of intestinal P-glycoprotein by ritonavir causes increased darunavir absorption Mus musculus
verapamil
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + darunavir/in
-
 Mus musculus ADP + phosphate + darunavir/out
-
 ?
ATP + H2O + ritonavir/in
-
 Mus musculus ADP + phosphate + ritonavir/out
-
 ?