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Literature summary for 7.6.2.2 extracted from
- H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein (2011), Cancer Chemother. Pharmacol., 67, 1017-1025.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1beta,1'beta)-5-bromo-6,6',7,12-tetramethoxy-2-methylberbaman | is an effectively and potential agent in reversing Pgp-mediated multidrug resistance by inhibiting the transport function and expression of Pgp | Homo sapiens |  |
| tetrandrine | i.e (1beta,1'beta)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| ubiquitination | H1 prompts the degradation of Pgp and decreases Pgp protein half-life by enhancing the ubiquitination of Pgp | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| KBv200 cell | - |
Homo sapiens | - |
| MCF-7/adr cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? | |
| ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pgp | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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