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Literature summary for 7.6.2.2 extracted from

  • Patel, K.J.; Tannock, I.F.
    The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors (2009), BMC Cancer, 9, 356.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
PSC 833 PgP inhibitors increase uptake of doxorubicin in tumor cells close to blood vessels, have little effect on drug uptake into tumor cells at intermediate distances, and might have a paradoxical effect to decrease doxorubicin uptake into distal tumor cells. This effect probably contributes to the limited success of PgP inhibitors in clinical trials Mus musculus
verapamil PgP inhibitors increase uptake of doxorubicin in tumor cells close to blood vessels, have little effect on drug uptake into tumor cells at intermediate distances, and might have a paradoxical effect to decrease doxorubicin uptake into distal tumor cells. This effect probably contributes to the limited success of PgP inhibitors in clinical trials Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + doxorubicin/in Mus musculus
-
 ADP + phosphate + doxorubicin/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + doxorubicin/in
-
 Mus musculus ADP + phosphate + doxorubicin/out
-
 ?

Synonyms

Synonyms Comment Organism
P-glycoprotein
-
 Mus musculus