Literature summary for 7.6.2.2 extracted from

Hemauer, S.J.; Patrikeeva, S.L.; Nanovskaya, T.N.; Hankins, G.D.; Ahmed, M.S.
Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles (2009), Biochem. Pharmacol., 78, 1272-1278.

Search for more literature for 7.6.2.2

Inhibitors

Inhibitors	Comment	Organism	Structure
buprenorphine	inhibits paclitaxel transport, placental brush border membrane vesicles	Homo sapiens
methadone	inhibits paclitaxel transport, placental brush border membrane vesicles	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	placental apical membrane, preparation of brush border membrane inside-out vesicles	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + paclitaxel/in	-	Homo sapiens	ADP + phosphate + paclitaxel/out	-	?

Synonyms

Synonyms	Comment	Organism
P-glycoprotein	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.018	-	methadone	22°C, pH 7.4, inhibition of paclitaxel transport	Homo sapiens
0.044	-	buprenorphine	22°C, pH 7.4, inhibition of paclitaxel transport	Homo sapiens
0.09	-	buprenorphine	22°C, pH 7.4, inhibition of paclitaxel transport	Homo sapiens

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Release 2023.1 (January 2023)