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Literature summary for 7.6.2.2 extracted from
- Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells (2009), Ann. N. Y. Acad. Sci., 1171, 132-136.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| wogonin | impairs the function of P-glycoprotein and increases cellular content of etoposide in HL-60 cells. Wogonin may be used to reduce the excretion of anticancer agents via P-glycoprotein and to increase the pharmacological action in cancer cells. Wogonin may play a role in overcoming multidrug resistance | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P-glycoprotein | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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