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Literature summary for 7.6.2.2 extracted from
- Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility (2009), Mol. Biochem. Parasitol., 167, 54-59.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | praziquantel, a drug used against schistosomiasis, transiently induces expression of SMDR2 in adult worms | Schistosoma mansoni |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| SMDR2, expression analysis | Schistosoma mansoni |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Schistosoma mansoni |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic/in | Schistosoma mansoni | SMDR2 is an ATP-dependent efflux pump involved in transport of toxins and xenobiotics from cells | ADP + phosphate + xenobiotic/out | - |
? | |
| additional information | Schistosoma mansoni | adult worms from the Egyptian Schistosoma mansoni isolate with reduced sensitivity to praziquantel express increased levels of SMDR2 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | - |
SMDR2, Egyptian isolate propagated in female Swiss Webster mice | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic/in | - |
Schistosoma mansoni | ADP + phosphate + xenobiotic/out | - |
? | |
| ATP + H2O + xenobiotic/in | SMDR2 is an ATP-dependent efflux pump involved in transport of toxins and xenobiotics from cells | Schistosoma mansoni | ADP + phosphate + xenobiotic/out | - |
? | |
| additional information | adult worms from the Egyptian Schistosoma mansoni isolate with reduced sensitivity to praziquantel express increased levels of SMDR2 | Schistosoma mansoni | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | P-glycoprotein is a member of the ATP-binding-cassette superfamily of proteins | Schistosoma mansoni |
| P-glycoprotein | - |
Schistosoma mansoni |
| SMDR2 | - |
Schistosoma mansoni |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Schistosoma mansoni | |
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Release 2023.1 (January 2023)
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