Cloned (Comment) | Organism |
---|---|
overexpression of P-glycoprotein, MRP1, or BCRP in NIH-3T3 cells and in Leishmania tropica | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2aR,6aR,12bS,14bS)-10,17-dimethoxy-3,3,6,6-tetramethyl-2a,3,6a,7,12b,14b-hexahydro-2H,6H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[3,2-h]chromene-13,14-dione | inhibits Pgp- and MDR1-mediated daunorubicin transport in NIH-3T3 MDR1 cells | Homo sapiens | |
(2aR,6aS,12bR,14bS)-10,17-dimethoxy-3,3,6,6-tetramethyl-2a,3,6a,7,12b,14b-hexahydro-2H,6H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[3,2-h]chromene-13,14-dione | inhibits Pgp- and MDR1-mediated daunorubicin transport in NIH-3T3 MDR1 cells | Homo sapiens | |
(2R,4aR,7bR,9R,11aR,14bR)-2,5,5,9,12,12-hexamethyl-1,3,4,4a,5,8,9,10,11,11a,12,14b-dodecahydrobenzo[c]isochromeno[3,4-g]chromene-7,14(2H,7bH)-dione | inhibits Pgp- and MDR1-mediated daunorubicin transport in NIH-3T3 MDR1 cells | Homo sapiens | |
(6aS,9bR,15aS,18bR)-2,4,11,13-tetrabromo-7,7,16,16-tetramethyl-6a,15a,16,18b-tetrahydro-6H,15H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[2,3-g]chromene-9,18(7H,9bH)-dione | inhibits Pgp- and MDR1-mediated daunorubicin transport in NIH-3T3 MDR1 cells | Homo sapiens | |
(6aS,9bR,15aS,18bR)-3,12-dimethoxy-7,7,16,16-tetramethyl-6a,15a,16,18b-tetrahydro-6H,15H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[2,3-g]chromene-9,18(7H,9bH)-dione | inhibits Pgp- and MDR1-mediated daunorubicin transport in NIH-3T3 MDR1 cells | Homo sapiens | |
additional information | inhibitor effects on daunorubicin resistance and cell growth, overview | Homo sapiens | |
verapamil | - |
Homo sapiens | |
zosuquidar | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic/in | Homo sapiens | - |
ADP + phosphate + xenobiotic/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + daunorubicin/in | - |
Homo sapiens | ADP + phosphate + daunorubicin/out | - |
? | |
ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCRP | - |
Homo sapiens |
MRP1 | - |
Homo sapiens |
P-glycoprotein | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00042 | - |
(2aR,6aS,12bR,14bS)-10,17-dimethoxy-3,3,6,6-tetramethyl-2a,3,6a,7,12b,14b-hexahydro-2H,6H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[3,2-h]chromene-13,14-dione | recombinant MDR1in NIH-3T3 cells | Homo sapiens | |
0.00051 | - |
(6aS,9bR,15aS,18bR)-3,12-dimethoxy-7,7,16,16-tetramethyl-6a,15a,16,18b-tetrahydro-6H,15H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[2,3-g]chromene-9,18(7H,9bH)-dione | recombinant MDR1in NIH-3T3 cells | Homo sapiens | |
0.00077 | - |
(2R,4aR,7bR,9R,11aR,14bR)-2,5,5,9,12,12-hexamethyl-1,3,4,4a,5,8,9,10,11,11a,12,14b-dodecahydrobenzo[c]isochromeno[3,4-g]chromene-7,14(2H,7bH)-dione | recombinant MDR1in NIH-3T3 cells | Homo sapiens | |
0.001 | - |
(2aR,6aR,12bS,14bS)-10,17-dimethoxy-3,3,6,6-tetramethyl-2a,3,6a,7,12b,14b-hexahydro-2H,6H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[3,2-h]chromene-13,14-dione | recombinant MDR1in NIH-3T3 cells | Homo sapiens | |
0.001 | - |
(6aS,9bR,15aS,18bR)-2,4,11,13-tetrabromo-7,7,16,16-tetramethyl-6a,15a,16,18b-tetrahydro-6H,15H-chromeno[3,4-c]chromeno[4',3':4,5]pyrano[2,3-g]chromene-9,18(7H,9bH)-dione | recombinant MDR1in NIH-3T3 cells | Homo sapiens |