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Literature summary for 7.6.2.2 extracted from

  • Koehn, J.; Fountoulakis, M.; Krapfenbauer, K.
    Multiple drug resistance associated with function of ABC-transporters in diabetes mellitus: molecular mechanism and clinical relevance (2008), Infect. Disord. Drug Targets, 8, 109-118.
    View publication on PubMed
Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
MRP1/ABCC1, DNA and amino acid sequence determination and analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
T2D mutation of two tyrosine residues in MRP1 cannot alter the sensitivity to glibenclamide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
glibenclamide mutation of residue Tyr2 in MRP1 cannot alter the sensitivity to glibenclamide Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane MRP1 possesses three transmembrane domains, TMD0, TMD1, and TMD2 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MRP1 is a primary active transporter of conjugated metabolites and endogenous organic anions including leukotriene C4 and glutathione. Enzyme mutations can lead to diabetes mellitus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
insulinoma cell primary cells Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic beta cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MRP1 is a primary active transporter of conjugated metabolites and endogenous organic anions including leukotriene C4 and glutathione. Enzyme mutations can lead to diabetes mellitus Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More membrane topology, MRP1 domain arrangement, structure analysis and comparison, overview Homo sapiens

Synonyms

Synonyms Comment Organism
MRP1/ABCC1
-
 Homo sapiens
multidrug resistance protein 1
-
 Homo sapiens