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Literature summary for 7.6.2.2 extracted from
- Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice (2009), Drug Metab. Dispos., 37, 203-210.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| determination tissue and developmental expression patterns of genes Mdr1a, Mdr1b, and Mdr2, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic/in | Mus musculus | - |
ADP + phosphate + xenobiotic/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6J mice, genes Mdr1a, Mdr1b, and Mdr2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| colon | - |
Mus musculus | - |
| duodenum | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| ileum | - |
Mus musculus | - |
| jejunum | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | isozymes Mdr1a and Mdr1b show a developmental pattern of low expression at birth, followed by a gradual increase to mature levels at approximately 30 days of age in all tissues. In contrast, Mdr2 mRNA in liver is markedly up-regulated at birth, which returns to low levels by 5 days of age and then gradually increases to mature levels. The three Mdr transporters in mice are expressed in a tissue-specific and age-dependent pattern, there are gender differences in expression, and Mdr transporters are inducible by only a few microsomal enzyme inducers | Mus musculus | - |
| ovary | - |
Mus musculus | - |
| placenta | - |
Mus musculus | - |
| stomach | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic/in | - |
Mus musculus | ADP + phosphate + xenobiotic/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mdr1a | - |
Mus musculus |
| MDR1b | - |
Mus musculus |
| Mdr2 | - |
Mus musculus |
| multidrug resistance transporter | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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