Literature summary for 7.6.2.2 extracted from

Becker, J.P.; Depret, G.; Van Bambeke, F.; Tulkens, P.M.; Prevost, M.
Molecular models of human P-glycoprotein in two different catalytic states (2009), BMC Struct. Biol., 9, 3.

Search for more literature for 7.6.2.2

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	a transmembrane protein	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + xenobiotic/in	Homo sapiens	P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes	ADP + phosphate + xenobiotic/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene mdr1 encoding P-gp	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2]	P-gp mediated-transport mechanism, overview	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + xenobiotic/in	P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes	Homo sapiens	ADP + phosphate + xenobiotic/out	-	?
ATP + H2O + xenobiotic/in	a cluster of aromatic residues located at the interface between the nucleotide binding domain and the transmembrane domain in opposite halves of the molecule may contribute to this signal transmission upon ATP binding and hydrolysis, binding and/or hydrolysis of ATP induce conformational changes that are transmitted from the nucleotide binding domains to the transmembrane domains, overview	Homo sapiens	ADP + phosphate + xenobiotic/out	-	?
additional information	ligand binding structure analysis using the three-dimensional structure modelling, overview	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	three-dimensional models of two different catalytic states of Pglycoprotein are developed based on the crystal structures of two bacterial multidrug transporters, molecular docking, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
More	P-glycoprotein belongs to the family of ATP-binding cassette proteins	Homo sapiens
P-glycoprotein	-	Homo sapiens
P-gp	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	binding and/or hydrolysis of ATP induce conformational changes that are transmitted from the nucleotide binding domains to the transmembrane domains	Homo sapiens

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Release 2023.1 (January 2023)