Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cis-(Z)-flupentixol | is a non-competitive inhibitor that interacts with the substrate site but is not transported | Homo sapiens | |
curcumin | modulates Pgp expression | Homo sapiens | |
praeruptorin A | modulates Pgp expression | Homo sapiens | |
XR9576 | is a non-competitive inhibitor that interacts with the substrate site but is not transported | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
170000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic/in | Homo sapiens | P-glycoprotein is a membrane ATP-driven drug exporter, Pgp actively extrudes a spectrum of hydrophobic xenobiotics, including a number of anticancer drugs | ADP + phosphate + xenobiotic/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene MDR1 encoding Pgp | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? | |
ATP + H2O + paclitaxel/in | - |
Homo sapiens | ADP + phosphate + paclitaxel/out | - |
? | |
ATP + H2O + puromycin/in | - |
Homo sapiens | ADP + phosphate + puromycin/out | - |
? | |
ATP + H2O + vinblastine/in | - |
Homo sapiens | ADP + phosphate + vinblastine/out | - |
? | |
ATP + H2O + xenobiotic/in | structure-activity relationship, overview | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
ATP + H2O + xenobiotic/in | P-glycoprotein is a membrane ATP-driven drug exporter, Pgp actively extrudes a spectrum of hydrophobic xenobiotics, including a number of anticancer drugs | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P-glycoprotein | - |
Homo sapiens |
Pgp | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |