Cloned (Comment) | Organism |
---|---|
gene ABCB1 maps to chromosome 7q21.1, expression of MDR1 in L5178 mouse T-cell lymphoma cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine | - |
Homo sapiens | |
Promethazine | - |
Homo sapiens | |
semi-beta-carotene-epoxide | - |
Homo sapiens | |
tomato lectin | - |
Homo sapiens | |
verapamil | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic/in | Homo sapiens | P-gp 170 has two potentially interesting regions for drugs interfering with its efflux function, namely the oligosaccharides on the first extracellular loop with unknown function and the two intracellular ATP-binding regions providing the energy for drug efflux function. P-gp is a polytopic plasma membrane protein whose overexpression causes multidrug resistance, MDR, responsible for the failure of cancer chemotherapy | ADP + phosphate + xenobiotic/out | - |
? | |
additional information | Homo sapiens | The polylactoseamine oligosaccharides on the first loop of P-gp 170 can specifically bind the tomato lectin which possibly stabilizes the functional active conformation of P-gp | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene ABCB1 encoding MDR1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | P-gp is a highly glycosylated plasma membrane protein that exists in several glycoforms, with different degrees of glycosylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain capillary endothelial cell line | - |
Homo sapiens | - |
colonic epithelium | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + rhodamine 123 /in | - |
Homo sapiens | ADP + phosphate + rhodamine 123 /out | - |
? | |
ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
ATP + H2O + xenobiotic/in | P-gp 170 has two potentially interesting regions for drugs interfering with its efflux function, namely the oligosaccharides on the first extracellular loop with unknown function and the two intracellular ATP-binding regions providing the energy for drug efflux function. P-gp is a polytopic plasma membrane protein whose overexpression causes multidrug resistance, MDR, responsible for the failure of cancer chemotherapy | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
additional information | The polylactoseamine oligosaccharides on the first loop of P-gp 170 can specifically bind the tomato lectin which possibly stabilizes the functional active conformation of P-gp | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABCB1 | - |
Homo sapiens |
MDR1 | - |
Homo sapiens |
More | P-gp 170 is a member of the ATP-binding cassette, ABC, transporter superfamily | Homo sapiens |
P-gp | - |
Homo sapiens |
PGY1 | - |
Homo sapiens |
phospho-glycoprotein | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |