Literature summary for 7.6.2.2 extracted from

Limtrakul, P.; Chearwae, W.; Shukla, S.; Phisalphong, C.; Ambudkar, S.V.
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin (2007), Mol. Cell. Biochem., 296, 85-95.

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Activating Compound

Activating Compound	Comment	Organism	Structure
tetrahydrocurcumin	inhibitory to P-glycoprotein as well as to mitoxantrone resistance protein and multidrug resistance protein1. Inhibition of transport function with concomitant up to 2.6fold stimulation of ATPase activity	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in KB-3-1 cell, KB-V-1 and MCF-7 cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
tetrahydrocurcumin	inhibitory to P-glycoprotein as well as to mitoxantrone resistance protein and multidrug resistance protein1. Inhibition of transport function with concomitant stimulation of ATPase activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform ABCB1	-

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Release 2023.1 (January 2023)