Literature summary for 7.6.2.2 extracted from

Zastre, J.; Jackson, J.K.; Wong, W.; Burt, H.M.
Methoxypolyethylene glycol-block-polycaprolactone diblock copolymers reduce P-glycoprotein efflux in the absence of a membrane fluidization effect while stimulating P-glycoprotein ATPase activity (2007), J. Pharm. Sci., 96, 864-875.

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Activating Compound

Activating Compound	Comment	Organism	Structure
methoxypolyethylene17 glycol-beta-caprolactone5	amphiphilic diblock copolymer, decreases membrane fluidity and inhibits enzyme-mediated efflux while stimulating the enzyme's ATPase activity up to 3fold	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
methoxypolyethylene17 glycol-beta-caprolactone5	amphiphilic diblock copolymer, decreases membrane fluidity and inhibits enzyme-mediated efflux while stimulating the enzyme's ATPase activity up to 3fold	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)