Literature summary for 7.6.2.2 extracted from

Mueller, M.; Klein, I.; Kopacsi, S.; Remaley, A.T.; Rajnavoelgyi, E.; Sarkadi, B.; Varadi, A.
Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstane stimulated membrane ATPase activity (2006), FEBS Lett., 580, 6139-6144.

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Activating Compound

Activating Compound	Comment	Organism	Structure
3-doxyl-17beta-hydroxy-5alpha-androstane	stimulation of ATPase-activity arising from co-expression of isoforms ABCG5 and ABCG8	Homo sapiens
4-androstene-3,17-dione	stimulation of ATPase-activity arising from co-expression of isoforms ABCG5 and ABCG8	Homo sapiens
5-androsten-3beta-ol-17-one	stimulation of ATPase-activity arising from co-expression of isoforms ABCG5 and ABCG8	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression of isoforms ABCG5 and ABCG8 in insect cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	co-expression of isoforms ABCG5 and ABCG8 in insect cells results in presence of a vanadate-sensitive ATPase activity in the membrane	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
progesterone	inhibition of ATPase-activity arising from co-expression of isoforms ABCG5 and ABCG8	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms ABCG5 and ABCG8	-

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Release 2023.1 (January 2023)