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Literature summary for 7.6.2.2 extracted from

  • Chang, C.; Bahadduri, P.M.; Polli, J.E.; Swaan, P.W.; Ekins, S.
    Rapid identification of P-glycoprotein substrates and inhibitors (2006), Drug Metab. Dispos., 34, 1976-1984.
    View publication on PubMed
Search for more literature for 7.6.2.2

Application

Application Comment Organism
analysis use of pharmacophore models for the prediction of binding to P-glycoprotein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in MDCK cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acitretin
-
 Homo sapiens
cholecalciferol
-
 Homo sapiens
miconazole
-
 Homo sapiens
misoprostol
-
 Homo sapiens
nafcillin
-
 Homo sapiens
repaglinide
-
 Homo sapiens
salmeterol
-
 Homo sapiens
telmisartan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform ABCB1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + acitretin/in
-
 Homo sapiens ADP + phosphate + acitretin/out
-
 ?
ATP + H2O + misoprostol/in
-
 Homo sapiens ADP + phosphate + misoprostol/out
-
 ?
ATP + H2O + repaglinide/in
-
 Homo sapiens ADP + phosphate + repaglinide/out
-
 ?
ATP + H2O + salmeterol/in
-
 Homo sapiens ADP + phosphate + salmeterol/out
-
 ?
ATP + H2O + telmisartan/in
-
 Homo sapiens ADP + phosphate + telmisartan/out
-
 ?