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Literature summary for 7.6.2.2 extracted from
- Functional characterization of the Saccharomyces cerevisiae ABC-transporter Yor1p overexpressed in plasma membranes (2008), Biochim. Biophys. Acta, 1778, 68-78.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E1392Q | loss of ATPase activity | Saccharomyces cerevisiae |
| H123R | loss of ATPase activity | Saccharomyces cerevisiae |
| additional information | overexpression of Yor1p confers resistance to oligomycin, rhodamine 6G and rhodamine B to cells. A yor1 gene disruption mutant is hypersensitive to oligomycin and rhomdamine 6G | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| doxorubicin | - |
Saccharomyces cerevisiae |  |
| N-ethylmaleimide | partial | Saccharomyces cerevisiae | |
| oligomycin | inhibition of ATPase activity | Saccharomyces cerevisiae | |
| rhodamine 101 | - |
Saccharomyces cerevisiae | |
| rhodamine 6G | - |
Saccharomyces cerevisiae | |
| rhodamine B | - |
Saccharomyces cerevisiae | |
| vanadate | - |
Saccharomyces cerevisiae | |
| verapamil | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
ATP | pH 7.5, 37°C | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
isoform Yor1p | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0011 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | rhodamine 101 | |
| 0.0012 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | rhodamine 6G | |
| 0.0059 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | rhodamine B | |
| 0.0069 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | oligomycin | |
| 0.042 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | verapamil | |
| 0.073 | - |
pH 7.5, 37°C | Saccharomyces cerevisiae | doxorubicin | |
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