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Literature summary for 7.6.2.2 extracted from

  • Tombline, G.; Donnelly, D.J.; Holt, J.J.; You, Y.; Ye, M.; Gannon, M.K.; Nygren, C.L.; Detty, M.R.
    Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state (2006), Biochemistry, 45, 8034-8047.
    View publication on PubMed
Search for more literature for 7.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
3,6-bis(dimethylamino)-9-(3-aminophenyl)-thioxanthylium hexafluorophosphate
-
 Mus musculus
3,6-bis(dimethylamino)-9-(3-methoxyphenyl)-xanthylium hexafluorophosphate
-
 Mus musculus
3,6-bis(dimethylamino)-9-(3-phenoxypropyl)-thioxanthylium hexafluorophosphate
-
 Mus musculus
3,6-bis(dimethylamino)-9-(N,N-diethyl-5-thiophene-2-carboxamide)selenoxanthylium hexafluorophosphate
-
 Mus musculus
3,6-bis(dimethylamino)-9-(N,N-diethyl-5-thiophene-2-carboxamide)thioxanthylium hexafluorophosphate
-
 Mus musculus
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide
-
 Mus musculus
3,6-bis(dimethylamino)-9-phenyl-thioxanthylium bromide
-
 Mus musculus
rhodamine 123
-
 Mus musculus
rhodamine 6G
-
 Mus musculus
tetramethylrosamine
-
 Mus musculus
verapamil
-
 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Pichia pastoris Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-(N,N-diethyl-5-thiophene-2-carboxamide)thioxanthylium hexafluorophosphate Mus musculus
0.006
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-(N,N-diethyl-5-thiophene-2-carboxamide)selenoxanthylium hexafluorophosphate Mus musculus
0.007
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-(3-methoxyphenyl)-xanthylium hexafluorophosphate Mus musculus
0.009
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-(3-phenoxypropyl)-thioxanthylium hexafluorophosphate Mus musculus
0.018
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-(3-aminophenyl)-thioxanthylium hexafluorophosphate Mus musculus
0.02
-
 ATP pH 7.4, 37°C, presence of verapamil Mus musculus
0.026
-
 ATP pH 7.4, 37°C, presence of rhodamine 6G Mus musculus
0.064
-
 ATP pH 7.4, 37°C, presence of tetramethylrosamine Mus musculus
0.07
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-phenyl-thioxanthylium bromide Mus musculus
0.074
-
 ATP pH 7.4, 37°C, presence of 3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide Mus musculus
0.231
-
 ATP pH 7.4, 37°C, presence of rhodamine 123 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?