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Literature summary for 7.6.2.2 extracted from
- Characterization of beta-adrenoceptor antagonists as substrates and inhibitors of the drug transporter P-glycoprotein (2006), Fundam. Clin. Pharmacol., 20, 273-282.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bisoprolol | - |
Homo sapiens |  |
| carvedilol | - |
Homo sapiens | |
| propranolol | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + digoxin/in | - |
Homo sapiens | ADP + phosphate + digoxin/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P-glycoprotein | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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