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Literature summary for 7.6.2.2 extracted from
- A kinetic study of rhodamine123 pumping by P-glycoprotein (2006), Biochim. Biophys. Acta, 1758, 1671-1676.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| verapamil | inhibits efflux of rhodamine 123 uncompetitively | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + rhodamine 123/in | Homo sapiens | the enzyme plays an important role in drug resistance | ADP + phosphate + rhodamine 123/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| K-562 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
| ATP + H2O + rhodamine 123/in | the enzyme plays an important role in drug resistance | Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MDR1 P-glycoprotein | - |
Homo sapiens |
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