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Literature summary for 7.6.2.2 extracted from
- P-glycoproteins and multidrug resistance (1996), Annu. Rev. Pharmacol. Toxicol., 36, 161-183.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Xenopus oocytes | Mus musculus |
| expression in Xenopus oocytes | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | 140000 | P-glycoprotein | Homo sapiens |
| 190000 | - |
1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | energy-dependent drug efflux pump | ? | - |
? |  |
| additional information | Homo sapiens | energy-dependent drug efflux pump | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetinae | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | one glycosylation site is in the second half of the P-glycoprotein, the second glycosylation site links transmembrane domains 8 and 9 in the traditional model of the P-glycoprotein topology | Mus musculus |
| glycoprotein | one glycosylation site is in the second half of the P-glycoprotein, the second glycosylation site links transmembrane domains 8 and 9 in the traditional model of the P-glycoprotein topology | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| RPMI-8226 cell | RPMI 8226 myeloma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| colchicine/in + ATP + H2O | - |
Homo sapiens | colchicine/out + ADP + phosphate | - |
? | |
| doxorubicin/in + ATP + H2O | - |
Homo sapiens | doxorubicin/out + ADP + phosphate | - |
? | |
| leukotriene C4/in + ATP + H2O | - |
Mus musculus | leukotriene C4/out + ADP + phosphate | - |
? | |
| leukotriene C4/in + ATP + H2O | - |
Homo sapiens | leukotriene C4/out + ADP + phosphate | - |
? | |
| leukotriene D4/in + ATP + H2O | - |
Homo sapiens | leukotriene D4/out + ADP + phosphate | - |
? | |
| leukotriene E4/in + ATP + H2O | - |
Homo sapiens | leukotriene E4/out + ADP + phosphate | - |
? | |
| additional information | energy-dependent drug efflux pump | Mus musculus | ? | - |
? | |
| additional information | energy-dependent drug efflux pump | Homo sapiens | ? | - |
? | |
| S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O | - |
Homo sapiens | S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate | - |
? | |
| vincristine/in + ATP + H2O | - |
Mus musculus | vincristine/out + ADP + phosphate | - |
? | |
| vincristine/in + ATP + H2O | - |
Homo sapiens | vincristine/out + ADP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence | Homo sapiens |
| More | the P-glycoprotein contains 12 transmembrane domains with 6 extracellular loops and 2 cytoplasmic ATP-binding domains | Homo sapiens |
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