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Literature summary for 7.6.2.15 extracted from

  • Bian, J.; Shen, H.; Tu, Y.; Yu, A.; Li, C.
    The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola (2011), J. Bacteriol., 193, 3912-3922 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + thiamine diphosphate-[thiamine-binding protein ThiB][side 1] Treponema denticola
-
 ADP + phosphate + thiamine diphosphate[side 2] + [thiamine-binding protein ThiB][side 1]
-
 ?
ATP + H2O + thiamine diphosphate-[thiamine-binding protein ThiB][side 1] Treponema denticola ATCC 35405
-
 ADP + phosphate + thiamine diphosphate[side 2] + [thiamine-binding protein ThiB][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Treponema denticola
-
-
-
Treponema denticola ATCC 35405
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + thiamine diphosphate-[thiamine-binding protein ThiB][side 1]
-
 Treponema denticola ADP + phosphate + thiamine diphosphate[side 2] + [thiamine-binding protein ThiB][side 1]
-
 ?
ATP + H2O + thiamine diphosphate-[thiamine-binding protein ThiB][side 1]
-
 Treponema denticola ATCC 35405 ADP + phosphate + thiamine diphosphate[side 2] + [thiamine-binding protein ThiB][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
tbpABC operon name Treponema denticola
thiamine pyrophosphate ABC transporter the enzyme consists of a thiamine diphosphate-binding protein (TDE0143), a transmembrane permease (TDE0144), and a cytosolic ATPase (TDE0145) Treponema denticola
TPP ABC transporter
-
 Treponema denticola

Expression

Organism Comment Expression
Treponema denticola the expression level of the enzyme is negatively regulated by high concentrations of exogenous thiamine diphosphate down

General Information

General Information Comment Organism
malfunction the TDE0143 deletion mutant has a decreased ability to transport exogenous thiamine diphosphate, and the mutant fails to grow when exogenous thiamine diphosphate is insufficient Treponema denticola
metabolism the enzyme is required for the uptake of exogenous thiamine diphosphate Treponema denticola