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Literature summary for 7.6.2.1 extracted from
- Proteomic analysis and functional characterization of P4-ATPase phospholipid flippases from murine tissues (2018), Sci. Rep., 8, 10795 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E181Q | the mutant shows strongly reduced activity compared to the wild type enzyme | Mus musculus |
| E186Q | inactive | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP-PNP | - |
Mus musculus |  |
| additional information | not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain | Mus musculus | |
| N-ethylmaleimide | - |
Mus musculus | |
| NaF | - |
Mus musculus | |
| vanadate | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Mus musculus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phospholipid[side 1] | Mus musculus | - |
ADP + phosphate + phospholipid[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O54827 | - |
- |
| Mus musculus | P70704 | - |
- |
| Mus musculus | P98197 | - |
- |
| Mus musculus | P98199 | - |
- |
| Mus musculus | P98200 | - |
- |
| Mus musculus | Q148W0 | - |
- |
| Mus musculus | Q6DFW5 | - |
- |
| Mus musculus | Q6UQ17 | - |
- |
| Mus musculus | Q8K2X1 | - |
- |
| Mus musculus | Q9QZW0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| retina | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylethanolamine[side 1] | - |
Mus musculus | ADP + phosphate + phosphatidylethanolamine[side 2] | - |
? | |
| ATP + H2O + phosphatidylserine[side 1] | - |
Mus musculus | ADP + phosphate + phosphatidylserine[side 2] | - |
? | |
| ATP + H2O + phospholipid[side 1] | - |
Mus musculus | ADP + phosphate + phospholipid[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 120000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATP10A | - |
Mus musculus |
| ATP10D | - |
Mus musculus |
| ATP11A | - |
Mus musculus |
| ATP11B | - |
Mus musculus |
| ATP11C | - |
Mus musculus |
| ATP8A1 | - |
Mus musculus |
| Atp8a2 | - |
Mus musculus |
| ATP8B1 | - |
Mus musculus |
| ATP8B2 | - |
Mus musculus |
| ATP8B3 | - |
Mus musculus |
| phospholipid flippase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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