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Literature summary for 7.6.2.1 extracted from

  • Perandres-Lopez, R.; Sanchez-Canete, M.P.; Gamarro, F.; Castanys, S.
    Functional role of highly conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase (2018), Biochem. J., 475, 887-899 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
F79A the mutation causes a considerable reduction in enzyme activity Leishmania sp.
N58A the mutation causes a considerable reduction in enzyme activity Leishmania sp.
Y65A the mutation causes a considerable reduction in enzyme activity Leishmania sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Leishmania sp. 5886
-

Organism

Organism UniProt Comment Textmining
Leishmania sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + miltefosine[side 1]
-
Leishmania sp. ADP + phosphate + miltefosine[side 2]
-
?
ATP + H2O + phosphatidylcholine[side 1]
-
Leishmania sp. ADP + phosphate + phosphatidylcholine[side 2]
-
?
ATP + H2O + phosphatidylethanolamine[side 1]
-
Leishmania sp. ADP + phosphate + phosphatidylethanolamine[side 2]
-
?

Synonyms

Synonyms Comment Organism
LMT translocase
-
Leishmania sp.
miltefosine transporter
-
Leishmania sp.
P4-ATPase
-
Leishmania sp.