BRENDA - Enzyme Database
show all sequences of 7.6.2.1

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Vestergaard, A.L.; Coleman, J.A.; Lemmin, T.; Mikkelsen, S.A.; Molday, L.L.; Vilsen, B.; Molday, R.S.; Dal Peraro, M.; Andersen, J.P.; Proc. Natl. Acad. Sci. USA 111, E1334-E1343 (2014)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
phosphatidylserine
stimulates the ATPase activity about 20fold
Bos taurus
Engineering
Amino acid exchange
Commentary
Organism
E371Q
affinity to phosphatidylserine similar to wild-type
Bos taurus
F354A
affinity to phosphatidylserine similar to wild-type
Bos taurus
F88A
tendency for inhibition at high substrate concentration
Bos taurus
I115A
biphasic phosphatidylserine concentration dependence with inhibition at the highest concentration
Bos taurus
I362A
increase in the apparent affinity for phosphatidylserine
Bos taurus
I364A
80% of wild-type activity
Bos taurus
I364E
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364F
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364M
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364Q
activation phase is followed by an inhibition phase at high phosphatidylserine concentration
Bos taurus
I364S
30% of wild-type activity
Bos taurus
K374A
affinity to phosphatidylserine similar to wild-type
Bos taurus
L112A
mutation does not appreciably affect Vmax, the apparent affinities for the substrates, or the phosphorylation rate
Bos taurus
L361A
affinity to phosphatidylserine similar to wild-type
Bos taurus
L367A
significant reduction in affinity to phosphatidylserine
Bos taurus
N359A
dramatic reduction of Vmax to 9-11% of wild-type
Bos taurus
N360A
increase in the apparent affinity for phosphatidylserine
Bos taurus
P363A
complete loss of activity
Bos taurus
S365A
significant reduction in affinity to phosphatidylserine
Bos taurus
T369A
increase in the apparent affinity for phosphatidylserine
Bos taurus
V906A
pronounced inhibition at high phosphatidylethanol concentration with only a slight inhibition at high phosphatidylserine concentration
Bos taurus
Y358A
affinity to phosphatidylserine similar to wild-type
Bos taurus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
ATP
mutant I364A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant I364S, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.019
-
ATP
mutant I364Q, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.02
-
ATP
mutant T369A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant V906A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.023
-
ATP
mutant N360A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.024
-
ATP
mutant I362A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.027
-
ATP
mutant F88A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.036
-
ATP
mutant Y358A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.038
-
ATP
wild-type, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.042
-
ATP
mutant F354A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.045
-
ATP
mutant L112A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.049
-
ATP
mutant E371Q, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant K374A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.058
-
ATP
mutant L361A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.068
-
ATP
mutant L367A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.073
-
ATP
mutant I115A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.103
-
ATP
mutant V906A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.104
-
ATP
mutant S365A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.105
-
ATP
mutant I364S, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.111
-
ATP
mutant I364E, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.131
-
ATP
mutant I364A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.148
-
ATP
mutant I364M, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.149
-
ATP
mutant I362A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.178
-
ATP
mutant I364F, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.22
-
ATP
mutant N359A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.25
-
ATP
mutant F88A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.288
-
ATP
mutant I364Q, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.292
-
ATP
mutant I364E, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.369
-
ATP
mutant I364M, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.371
-
ATP
wild-type, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.376
-
ATP
mutant I115A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.379
-
ATP
mutant L367A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.394
-
ATP
mutant L112A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.862
-
ATP
mutant S365A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
1.12
-
ATP
mutant I364F, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
2.215
-
ATP
mutant N359A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
C7EXK4
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O
-
735189
Bos taurus
ADP + phosphate
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
735189
Bos taurus
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
735189
Bos taurus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
additional information
during the transport across the membrane, the phosphatidylserine head group passes near residue I364. I364 is critical to the release of the transported lipid into the cytosolic leaflet. Transmembrane segment M4 residue N359 is involved in recognition of the lipid substrate on the exoplasmic side. Residue I364 and adjacent hydrophobic residues function as a hydrophobic gate that separates the entry and exit sites of the lipid and directs sequential formation and annihilation of water-filled cavities, thereby enabling transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane segments M1, M2, M4, and M6, with the hydrocarbon chains following passively, still in the membrane lipid phase
735189
Bos taurus
?
-
-
-
-
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
phosphatidylserine
stimulates the ATPase activity about 20fold
Bos taurus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
E371Q
affinity to phosphatidylserine similar to wild-type
Bos taurus
F354A
affinity to phosphatidylserine similar to wild-type
Bos taurus
F88A
tendency for inhibition at high substrate concentration
Bos taurus
I115A
biphasic phosphatidylserine concentration dependence with inhibition at the highest concentration
Bos taurus
I362A
increase in the apparent affinity for phosphatidylserine
Bos taurus
I364A
80% of wild-type activity
Bos taurus
I364E
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364F
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364M
3-5fold reduction in affinity for phosphatidylserine
Bos taurus
I364Q
activation phase is followed by an inhibition phase at high phosphatidylserine concentration
Bos taurus
I364S
30% of wild-type activity
Bos taurus
K374A
affinity to phosphatidylserine similar to wild-type
Bos taurus
L112A
mutation does not appreciably affect Vmax, the apparent affinities for the substrates, or the phosphorylation rate
Bos taurus
L361A
affinity to phosphatidylserine similar to wild-type
Bos taurus
L367A
significant reduction in affinity to phosphatidylserine
Bos taurus
N359A
dramatic reduction of Vmax to 9-11% of wild-type
Bos taurus
N360A
increase in the apparent affinity for phosphatidylserine
Bos taurus
P363A
complete loss of activity
Bos taurus
S365A
significant reduction in affinity to phosphatidylserine
Bos taurus
T369A
increase in the apparent affinity for phosphatidylserine
Bos taurus
V906A
pronounced inhibition at high phosphatidylethanol concentration with only a slight inhibition at high phosphatidylserine concentration
Bos taurus
Y358A
affinity to phosphatidylserine similar to wild-type
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
ATP
mutant I364A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant I364S, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.019
-
ATP
mutant I364Q, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.02
-
ATP
mutant T369A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant V906A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.023
-
ATP
mutant N360A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.024
-
ATP
mutant I362A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.027
-
ATP
mutant F88A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.036
-
ATP
mutant Y358A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.038
-
ATP
wild-type, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.042
-
ATP
mutant F354A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.045
-
ATP
mutant L112A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.049
-
ATP
mutant E371Q, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C; mutant K374A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.058
-
ATP
mutant L361A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.068
-
ATP
mutant L367A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.073
-
ATP
mutant I115A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.103
-
ATP
mutant V906A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.104
-
ATP
mutant S365A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.105
-
ATP
mutant I364S, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.111
-
ATP
mutant I364E, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.131
-
ATP
mutant I364A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.148
-
ATP
mutant I364M, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.149
-
ATP
mutant I362A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.178
-
ATP
mutant I364F, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.22
-
ATP
mutant N359A, presence of phosphatidylserine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.25
-
ATP
mutant F88A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.288
-
ATP
mutant I364Q, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.292
-
ATP
mutant I364E, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.369
-
ATP
mutant I364M, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.371
-
ATP
wild-type, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.376
-
ATP
mutant I115A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.379
-
ATP
mutant L367A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.394
-
ATP
mutant L112A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
0.862
-
ATP
mutant S365A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
1.12
-
ATP
mutant I364F, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
2.215
-
ATP
mutant N359A, presence of phosphatidylethanolamine, K0.5 value, pH 7.5, 37°C
Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O
-
735189
Bos taurus
ADP + phosphate
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
735189
Bos taurus
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
735189
Bos taurus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
additional information
during the transport across the membrane, the phosphatidylserine head group passes near residue I364. I364 is critical to the release of the transported lipid into the cytosolic leaflet. Transmembrane segment M4 residue N359 is involved in recognition of the lipid substrate on the exoplasmic side. Residue I364 and adjacent hydrophobic residues function as a hydrophobic gate that separates the entry and exit sites of the lipid and directs sequential formation and annihilation of water-filled cavities, thereby enabling transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane segments M1, M2, M4, and M6, with the hydrocarbon chains following passively, still in the membrane lipid phase
735189
Bos taurus
?
-
-
-
-
Other publictions for EC 7.6.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747035
Perandres-Lopez
Functional role of highly con ...
Leishmania sp.
Biochem. J.
475
887-899
2018
-
-
-
-
3
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747650
Takada
Phospholipid-flipping activit ...
Homo sapiens
EMBO J.
37
pii: e97705
2018
-
-
1
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
749361
Wang
Proteomic analysis and functi ...
Mus musculus
Sci. Rep.
8
10795
2018
-
-
-
-
2
-
5
-
1
-
-
10
-
11
-
-
-
-
-
5
-
-
30
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
20
-
-
50
-
-
10
-
-
10
-
-
-
-
-
31
-
-
30
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747894
Yamamoto
Cfs1p, a novel membrane prote ...
Saccharomyces cerevisiae
G3 (Bethesda)
7
179-192
2017
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
748628
Chalat
C-terminus of the P4-ATPase A ...
Bos taurus
Mol. Biol. Cell
28
452-462
2017
2
-
1
-
2
-
1
-
1
-
-
1
-
2
-
1
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
1
2
-
1
-
-
2
-
1
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748744
Takatsu
Phospholipid flippase ATP11C ...
Homo sapiens
Nat. Commun.
8
1423
2017
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
747188
van der Mark
The phospholipid flippase ATP ...
Homo sapiens
Biochim. Biophys. Acta
1863
2280-2288
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
747611
Roland
Decoding P4-ATPase substrate ...
Saccharomyces cerevisiae
Crit. Rev. Biochem. Mol. Biol.
51
513-527
2016
-
-
-
-
-
-
-
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1
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1
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1
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1
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2
-
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701013
Sanyal
Specific transbilayer transloc ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
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767-772
2009
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2
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1
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1
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1
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-
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701167
Gong
Expression of Atp8b3 in murine ...
Mus musculus
Reproduction
137
345-351
2009
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1
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1
1
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1
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1
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1
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1
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3
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1
-
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711622
Barber
Aminophospholipid translocase ...
Homo sapiens
Br. J. Haematol.
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447-455
2009
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1
1
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1
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1
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1
1
-
1
-
-
-
-
-
-
-
-
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2
2
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-
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712395
Coleman
Localization, purification, an ...
Bos taurus, Homo sapiens, Mus musculus
J. Biol. Chem.
284
32670-32679
2009
3
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3
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3
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3
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2
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1
11
3
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11
2
4
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3
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3
-
3
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3
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3
5
3
2
7
-
-
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2
1
11
3
-
11
2
4
-
-
-
3
-
-
-
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3
3
-
-
-
713280
Zhang
IRREGULAR TRICHOME BRANCH 2 (I ...
Arabidopsis thaliana
Plant J.
60
195-206
2009
-
-
1
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1
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4
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1
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1
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1
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1
-
-
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-
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-
-
-
-
-
-
-
2
2
-
-
-
685236
Liu
Role of phospholipid scramblas ...
Homo sapiens
Biochemistry
47
4518-4529
2008
1
-
-
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2
-
1
-
1
1
-
1
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1
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-
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1
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2
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1
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1
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1
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2
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1
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1
1
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1
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1
-
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2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688911
Liu
P4-ATPase requirement for AP-1 ...
Saccharomyces cerevisiae
Mol. Biol. Cell
19
3525-3535
2008
-
-
-
-
1
-
-
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4
-
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1
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2
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-
-
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1
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-
-
-
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1
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4
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696218
Sahu
Flippase activity in proteolip ...
Spinacia oleracea
Biochemistry
47
10481-10490
2008
-
-
-
-
-
-
2
-
4
1
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-
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4
-
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2
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2
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2
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4
1
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696241
Eckford
Interaction of the P-glycoprot ...
Cricetulus griseus
Biochemistry
47
13686-13698
2008
2
-
-
-
-
-
2
-
1
-
-
-
-
1
-
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1
-
-
1
-
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3
-
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-
-
-
-
-
-
-
-
-
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2
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-
-
-
-
-
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2
-
-
1
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-
-
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1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696283
Sanyal
Distinct flippases translocate ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YCF40
Biochemistry
47
7937-7946
2008
-
-
-
-
-
-
1
-
2
-
-
-
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4
-
-
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2
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1
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2
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697213
Poulsen
Flippases: still more question ...
Saccharomyces cerevisiae
Cell. Mol. Life Sci.
65
3119-3125
2008
1
-
-
-
-
-
-
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2
-
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2
-
1
-
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-
-
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4
-
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-
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1
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-
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2
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2
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697594
Masuda
Study of oxidized lipids as en ...
Homo sapiens
Drug Metab. Lett.
2
238-244
2008
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700292
Barta
Effects of monoglycerides on P ...
Homo sapiens
Mol. Pharm.
5
863-875
2008
-
-
-
-
-
-
2
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700953
Ruiz
Bioinformatics identification ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
105
15553-15557
2008
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
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1
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-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684674
Sahu
Phospholipid scramblases: an o ...
Caenorhabditis elegans, Homo sapiens, Mus musculus
Arch. Biochem. Biophys.
462
103-114
2007
-
-
3
-
1
-
-
-
9
3
2
7
-
7
-
4
-
-
-
6
-
-
14
2
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
1
-
-
-
-
-
15
7
3
7
-
-
9
-
-
14
-
-
14
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685132
Smriti
ATP-dependent transport of pho ...
Homo sapiens
Biochemistry
46
2249-2259
2007
-
-
-
-
-
-
2
-
1
1
-
2
-
2
-
-
-
-
-
1
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
1
-
2
-
-
-
-
-
1
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686022
Razmara
Glycoprotein IIb/IIIa blockade ...
Homo sapiens
Cell. Mol. Life Sci.
64
999-1008
2007
2
-
-
-
-
-
-
-
1
1
-
2
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686247
Zuellig
Aminophospholipid translocase ...
Caenorhabditis elegans
Curr. Biol.
17
994-999
2007
-
1
-
-
1
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686385
Camberg
Synergistic stimulation of Eps ...
Vibrio cholerae
EMBO J.
26
19-27
2007
2
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686682
Regev
Modulation of P-glycoprotein-m ...
Homo sapiens
FEBS J.
274
6204-6214
2007
1
-
1
-
1
-
-
-
2
1
-
1
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687006
Morita
Bile salt-dependent efflux of ...
Homo sapiens
Hepatology
46
188-199
2007
4
-
1
-
2
-
1
-
2
1
1
1
-
2
-
1
-
-
-
3
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
4
-
1
-
-
2
-
-
1
-
-
2
1
1
1
-
-
1
-
-
3
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687552
Papadopulos
Flippase activity detected wit ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae sec61
J. Biol. Chem.
282
15559-15568
2007
-
-
-
-
-
-
-
1
2
-
-
4
-
4
-
-
1
-
1
-
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
4
-
-
-
1
1
-
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687558
Stevens
The proton electrochemical gra ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae LMY65
J. Biol. Chem.
282
17563-17567
2007
-
-
-
-
-
-
-
-
2
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2
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687676
Tyurina
Nitrosative stress inhibits th ...
Homo sapiens
J. Biol. Chem.
282
8498-8509
2007
-
-
-
-
-
-
2
-
1
3
-
1
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
3
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688706
Leung
Persistence of procoagulant su ...
Homo sapiens
J. Thromb. Haemost.
5
560-570
2007
-
-
-
-
-
-
-
-
1
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-
1
-
2
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688902
Furuta
Endocytic recycling in yeast i ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
295-312
2007
-
-
1
-
1
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688907
Liu
Yeast P4-ATPases Drs2p and Dnf ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
487-500
2007
-
-
1
-
1
-
-
-
4
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689125
Wang
C. elegans mitochondrial facto ...
Caenorhabditis elegans
Nat. Cell Biol.
9
541-549
2007
1
-
-
-
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689249
Wyles
Nuclear interactions of topois ...
Homo sapiens
Nucleic Acids Res.
35
4076-4085
2007
-
-
1
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667438
Noji
Mutational analysis of the Lem ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
344
323-331
2006
-
-
-
-
1
-
-
-
3
1
-
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
4
-
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668247
Devaux
Proteins involved in lipid tra ...
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Chem. Phys. Lipids
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21
1
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1
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671002
Verhoeven
Prolonged storage of red blood ...
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Vox Sang.
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5
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1
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1
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685075
Paterson
Lipid specific activation of t ...
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Biochemistry
45
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1
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1
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2
1
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Soupene
Identification of an erythroid ...
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Br. J. Haematol.
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Perez-Victoria
Phospholipid translocation and ...
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Alder-Baerens
Loss of P4 ATPases Drs2p and D ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae EHY227
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690150
Chen
Roles for the Drs2p-Cdc50p com ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CCY 2811
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2006
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6
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Wolfs
Activated scramblase and inhib ...
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Cell. Mol. Life Sci.
62
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2005
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1
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5
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1
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669094
Camberg
Molecular analysis of the Vibr ...
Homo sapiens
J. Bacteriol.
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2005
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670455
Vishwakarma
New fluorescent probes reveal ...
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Org. Biomol. Chem.
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2005
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655136
Castegna
Modulation of phospholipid asy ...
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2004
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Saito
Cdc50p, a protein required for ...
Saccharomyces cerevisiae
Mol. Biol. Cell
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Chang
Chemical modification identifi ...
Rattus norvegicus
Biochemistry
43
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2004
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Natarajan
Drs2p-coupled aminophospholipi ...
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Proc. Natl. Acad. Sci. USA
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2004
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Perez-Victoria
Functional cloning of the milt ...
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Pomorski
Drs2p-related P-type ATPases D ...
Saccharomyces cerevisiae
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2003
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Doerrler
ATPase activity of the MsbA li ...
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277
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2002
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1
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654164
Herzing
The human aminophospholipid-tr ...
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2001
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654604
Romsicki
Phospholipid flippase activity ...
Mesocricetus auratus
Biochemistry
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2001
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Daleke
Identification and purificatio ...
Bos taurus, Homo sapiens
Biochim. Biophys. Acta
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2000
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Ding
Identification and functional ...
Bos taurus
J. Biol. Chem.
275
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Hessel
The transbilayer distribution ...
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Hrafnsdottir
Reconstitution and partial cha ...
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4198-4206
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Beleznay
Characterization of the correl ...
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Fuchs
Evidence for an ATP-independen ...
no activity in Xenopus laevis, Rattus norvegicus
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Vermeulen
Manipulation of the phosphatid ...
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Tang
A subfamily of P-type ATPase w ...
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Stimulation of erythrocyte mem ...
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Biochem. Mol. Biol. Int.
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Separation and characterizatio ...
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Auland
Reconstitution of ATP-dependen ...
Homo sapiens
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246836
Morris
Characterization of the Mg2+-A ...
Homo sapiens
Biochem. Mol. Biol. Int.
31
823-832
1993
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3
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246840
Beleznay
ATP-dependent aminophospholipi ...
Homo sapiens
Biochemistry
32
3146-3152
1993
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246847
Connor
Transbilayer, movement of phos ...
Homo sapiens
Biochim. Biophys. Acta
1066
37-42
1991
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5
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246841
Devaux
Control of the transmembrane p ...
Bos taurus, Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
Biotechnol. Appl. Biochem.
12
517-522
1990
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246846
Middelkoop
Involvement of ATP-dependent a ...
Homo sapiens
Biochim. Biophys. Acta
981
151-160
1989
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751691
Zachowski
Control of transmembrane lipi ...
Homo sapiens
Nature
340
75-76
1989
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