BRENDA - Enzyme Database
show all sequences of 7.6.2.1

Phospholipid flippases: Building asymmetric membranes and transport vesicles

Sebastian, T.T.; Baldridge, R.D.; Xu, P.; Graham, T.R.; Biochim. Biophys. Acta 1821, 1068-1077 (2012)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ALIS protein
-
Arabidopsis thaliana
CDC50A
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endosome
-
Arabidopsis thaliana
5768
-
endosome
-
Caenorhabditis elegans
5768
-
endosome
-
Saccharomyces cerevisiae
5768
-
endosome
-
Homo sapiens
5768
-
Golgi apparatus
-
Arabidopsis thaliana
5794
-
Golgi apparatus
-
Caenorhabditis elegans
5794
-
Golgi apparatus
-
Saccharomyces cerevisiae
5794
-
Golgi apparatus
-
Homo sapiens
5794
-
plasma membrane
-
Caenorhabditis elegans
5886
-
plasma membrane
-
Homo sapiens
5886
-
plasma membrane
-
Arabidopsis thaliana
5886
-
plasma membrane
-
Saccharomyces cerevisiae
5886
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
-
-
Caenorhabditis elegans
C7U324
-
-
Caenorhabditis elegans
G5EBH1
-
-
Caenorhabditis elegans
O18182
-
-
Caenorhabditis elegans
P91203
-
-
Caenorhabditis elegans
Q7YXV5
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
P32660
-
-
Saccharomyces cerevisiae
P39524
-
-
Saccharomyces cerevisiae
Q12674
-
-
Saccharomyces cerevisiae
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood platelet
-
Homo sapiens
-
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + phosphatidylethanolamine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits
Subunits
Commentary
Organism
heterodimer
-
Arabidopsis thaliana
heterodimer
-
Caenorhabditis elegans
heterodimer
-
Homo sapiens
heterodimer
-
Saccharomyces cerevisiae
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ALIS protein
-
Arabidopsis thaliana
CDC50A
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endosome
-
Arabidopsis thaliana
5768
-
endosome
-
Caenorhabditis elegans
5768
-
endosome
-
Homo sapiens
5768
-
endosome
-
Saccharomyces cerevisiae
5768
-
Golgi apparatus
-
Arabidopsis thaliana
5794
-
Golgi apparatus
-
Caenorhabditis elegans
5794
-
Golgi apparatus
-
Homo sapiens
5794
-
Golgi apparatus
-
Saccharomyces cerevisiae
5794
-
plasma membrane
-
Caenorhabditis elegans
5886
-
plasma membrane
-
Saccharomyces cerevisiae
5886
-
plasma membrane
-
Homo sapiens
5886
-
plasma membrane
-
Arabidopsis thaliana
5886
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood platelet
-
Homo sapiens
-
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + phosphatidylethanolamine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylethanolamine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
heterodimer
-
Arabidopsis thaliana
heterodimer
-
Caenorhabditis elegans
heterodimer
-
Homo sapiens
heterodimer
-
Saccharomyces cerevisiae
General Information
General Information
Commentary
Organism
malfunction
knockdown of ALA1 expression causes a cold-sensitive growth defect in plants
Arabidopsis thaliana
malfunction
P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility
Homo sapiens
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Arabidopsis thaliana
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Caenorhabditis elegans
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Homo sapiens
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Saccharomyces cerevisiae
General Information (protein specific)
General Information
Commentary
Organism
malfunction
knockdown of ALA1 expression causes a cold-sensitive growth defect in plants
Arabidopsis thaliana
malfunction
P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility
Homo sapiens
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Arabidopsis thaliana
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Caenorhabditis elegans
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Homo sapiens
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Saccharomyces cerevisiae
Other publictions for EC 7.6.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747035
Perandres-Lopez
Functional role of highly con ...
Leishmania sp.
Biochem. J.
475
887-899
2018
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3
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1
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1
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1
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3
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747650
Takada
Phospholipid-flipping activit ...
Homo sapiens
EMBO J.
37
pii: e97705
2018
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1
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1
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1
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1
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2
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1
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1
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1
1
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749361
Wang
Proteomic analysis and functi ...
Mus musculus
Sci. Rep.
8
10795
2018
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2
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5
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1
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10
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11
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5
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30
1
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20
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50
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10
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10
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31
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30
10
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747894
Yamamoto
Cfs1p, a novel membrane prote ...
Saccharomyces cerevisiae
G3 (Bethesda)
7
179-192
2017
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1
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2
2
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748628
Chalat
C-terminus of the P4-ATPase A ...
Bos taurus
Mol. Biol. Cell
28
452-462
2017
2
-
1
-
2
-
1
-
1
-
-
1
-
2
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1
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2
1
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1
2
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1
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2
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1
1
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1
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1
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1
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2
1
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748744
Takatsu
Phospholipid flippase ATP11C ...
Homo sapiens
Nat. Commun.
8
1423
2017
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-
-
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1
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2
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1
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1
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1
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2
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1
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1
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747188
van der Mark
The phospholipid flippase ATP ...
Homo sapiens
Biochim. Biophys. Acta
1863
2280-2288
2016
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-
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3
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6
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6
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2
2
-
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-
747611
Roland
Decoding P4-ATPase substrate ...
Saccharomyces cerevisiae
Crit. Rev. Biochem. Mol. Biol.
51
513-527
2016
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1
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1
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3
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1
1
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748627
Tanaka
The phospholipid flippase ATP ...
Homo sapiens
Mol. Biol. Cell
27
3883-3893
2016
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3
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1
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3
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1
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1
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1
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1
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2
2
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748976
Botella
ALA10, a phospholipid flippas ...
Arabidopsis thaliana
Plant Physiol.
170
1300-1314
2016
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3
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1
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3
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1
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2
1
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1
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2
1
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1
1
1
1
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749181
Roland
Directed evolution of a sphin ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
113
E4460-E4466
2016
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12
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1
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1
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2
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6
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12
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1
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1
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6
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733726
Lee
Transport through recycling en ...
Homo sapiens
EMBO J.
34
669-688
2015
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3
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1
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2
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1
2
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734307
Naito
Phospholipid flippase ATP10A t ...
Homo sapiens
J. Biol. Chem.
290
15004-15017
2015
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2
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4
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1
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3
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3
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1
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1
1
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734314
Ansari
Characterization of P4 ATPase ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
23110-23123
2015
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2
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6
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2
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4
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2
4
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-
747769
Vestergaard
Specific mutations in mammali ...
Bos taurus
FEBS Lett.
589
3908-3914
2015
-
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1
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14
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1
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1
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1
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1
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1
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14
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1
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1
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1
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748170
Takatsu
ATP9B, a P4-ATPase (a putativ ...
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J. Biol. Chem.
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4
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2
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2
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2
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4
1
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696241
Eckford
Interaction of the P-glycoprot ...
Cricetulus griseus
Biochemistry
47
13686-13698
2008
2
-
-
-
-
-
2
-
1
-
-
-
-
1
-
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1
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-
1
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3
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2
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2
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1
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1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696283
Sanyal
Distinct flippases translocate ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YCF40
Biochemistry
47
7937-7946
2008
-
-
-
-
-
-
1
-
2
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4
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2
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-
2
-
-
-
-
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-
-
-
-
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-
-
-
-
697213
Poulsen
Flippases: still more question ...
Saccharomyces cerevisiae
Cell. Mol. Life Sci.
65
3119-3125
2008
1
-
-
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-
-
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2
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2
-
1
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-
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4
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1
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-
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2
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-
2
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-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697594
Masuda
Study of oxidized lipids as en ...
Homo sapiens
Drug Metab. Lett.
2
238-244
2008
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700292
Barta
Effects of monoglycerides on P ...
Homo sapiens
Mol. Pharm.
5
863-875
2008
-
-
-
-
-
-
2
-
-
-
1
-
-
1
-
-
-
-
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2
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2
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-
-
-
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-
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2
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-
1
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-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700953
Ruiz
Bioinformatics identification ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
105
15553-15557
2008
-
-
-
-
-
-
-
-
1
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1
-
4
-
-
-
-
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-
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2
-
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-
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1
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-
1
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684674
Sahu
Phospholipid scramblases: an o ...
Caenorhabditis elegans, Homo sapiens, Mus musculus
Arch. Biochem. Biophys.
462
103-114
2007
-
-
3
-
1
-
-
-
9
3
2
7
-
7
-
4
-
-
-
6
-
-
14
2
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
1
-
-
-
-
-
15
7
3
7
-
-
9
-
-
14
-
-
14
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685132
Smriti
ATP-dependent transport of pho ...
Homo sapiens
Biochemistry
46
2249-2259
2007
-
-
-
-
-
-
2
-
1
1
-
2
-
2
-
-
-
-
-
1
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
1
-
2
-
-
-
-
-
1
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686022
Razmara
Glycoprotein IIb/IIIa blockade ...
Homo sapiens
Cell. Mol. Life Sci.
64
999-1008
2007
2
-
-
-
-
-
-
-
1
1
-
2
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
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-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686247
Zuellig
Aminophospholipid translocase ...
Caenorhabditis elegans
Curr. Biol.
17
994-999
2007
-
1
-
-
1
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
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-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686385
Camberg
Synergistic stimulation of Eps ...
Vibrio cholerae
EMBO J.
26
19-27
2007
2
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686682
Regev
Modulation of P-glycoprotein-m ...
Homo sapiens
FEBS J.
274
6204-6214
2007
1
-
1
-
1
-
-
-
2
1
-
1
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687006
Morita
Bile salt-dependent efflux of ...
Homo sapiens
Hepatology
46
188-199
2007
4
-
1
-
2
-
1
-
2
1
1
1
-
2
-
1
-
-
-
3
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
4
-
1
-
-
2
-
-
1
-
-
2
1
1
1
-
-
1
-
-
3
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687552
Papadopulos
Flippase activity detected wit ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae sec61
J. Biol. Chem.
282
15559-15568
2007
-
-
-
-
-
-
-
1
2
-
-
4
-
4
-
-
1
-
1
-
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
4
-
-
-
1
1
-
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687558
Stevens
The proton electrochemical gra ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae LMY65
J. Biol. Chem.
282
17563-17567
2007
-
-
-
-
-
-
-
-
2
-
-
2
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
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-
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2
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-
2
-
-
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-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687676
Tyurina
Nitrosative stress inhibits th ...
Homo sapiens
J. Biol. Chem.
282
8498-8509
2007
-
-
-
-
-
-
2
-
1
3
-
1
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
3
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688706
Leung
Persistence of procoagulant su ...
Homo sapiens
J. Thromb. Haemost.
5
560-570
2007
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688902
Furuta
Endocytic recycling in yeast i ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
295-312
2007
-
-
1
-
1
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688907
Liu
Yeast P4-ATPases Drs2p and Dnf ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
487-500
2007
-
-
1
-
1
-
-
-
4
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689125
Wang
C. elegans mitochondrial facto ...
Caenorhabditis elegans
Nat. Cell Biol.
9
541-549
2007
1
-
-
-
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689249
Wyles
Nuclear interactions of topois ...
Homo sapiens
Nucleic Acids Res.
35
4076-4085
2007
-
-
1
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667438
Noji
Mutational analysis of the Lem ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
344
323-331
2006
-
-
-
-
1
-
-
-
3
1
-
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668247
Devaux
Proteins involved in lipid tra ...
Bos taurus, Homo sapiens, Leishmania infantum, Rattus norvegicus, Saccharomyces cerevisiae
Chem. Phys. Lipids
141
119-132
2006
-
-
-
-
1
1
3
-
11
5
1
14
-
5
-
-
2
-
-
6
-
-
21
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
11
5
1
14
-
-
-
2
-
6
-
-
21
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671002
Verhoeven
Prolonged storage of red blood ...
Homo sapiens
Vox Sang.
91
244-251
2006
1
-
-
-
-
-
1
-
1
2
-
3
-
1
-
-
-
-
-
1
-
2
5
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
2
-
3
-
-
-
-
-
1
-
2
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
685075
Paterson
Lipid specific activation of t ...
Mus musculus
Biochemistry
45
5367-5376
2006
6
-
1
-
-
-
3
-
2
1
1
1
-
4
-
-
1
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
3
-
-
2
1
1
1
-
-
-
1
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685854
Soupene
Identification of an erythroid ...
Mus musculus
Br. J. Haematol.
133
436-438
2006
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687516
Perez-Victoria
Phospholipid translocation and ...
Leishmania donovani
J. Biol. Chem.
281
23766-23775
2006
-
-
-
-
-
-
-
-
1
-
-
2
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688899
Alder-Baerens
Loss of P4 ATPases Drs2p and D ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae EHY227
Mol. Biol. Cell
17
1632-1642
2006
-
-
-
-
1
-
-
-
4
1
-
7
-
3
-
-
-
-
-
-
-
-
13
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
1
-
7
-
-
-
-
-
-
-
-
13
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
690150
Chen
Roles for the Drs2p-Cdc50p com ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CCY 2811
Traffic
7
1503-1517
2006
-
-
1
-
1
-
-
-
4
-
-
2
-
3
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668223
Wolfs
Activated scramblase and inhib ...
Homo sapiens
Cell. Mol. Life Sci.
62
1514-1525
2005
1
-
-
-
-
-
3
-
1
1
-
2
-
1
-
-
-
-
-
1
-
-
5
-
1
-
-
-
1
-
-
-
-
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