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Literature summary for 7.6.2.1 extracted from

  • Barber, L.A.; Palascak, M.B.; Joiner, C.H.; Franco, R.S.
    Aminophospholipid translocase and phospholipid scramblase activities in sickle erythrocyte subpopulations (2009), Br. J. Haematol., 146, 447-455.
    View publication on PubMed
Search for more literature for 7.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
additional information APLT ius inhibited after in vitro dehydration of normal and sickle erythrocytes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 healthy persons and patients with sickle cell disease
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte sickle and healthy. Normally-hydrated sickle erythrocytes without external phosphatidylserine have active APLT and inactive phospholipid scramblase. phosphatidylserine-exposing sickle erythrocytes show inhibited APLT and active phospholipid scramblase. Sickle reticulocytes have active APLT and active phospholipid scramblase independent of external phosphatidylserine. Sickle erythrocytes dehydrated in vivo show the highest proportion of phosphatidylserine-exposing erythrocytes and markedly inhibited APLT. Normal and sickle erythrocytes dehydrated in vitro have moderately decreased APLT. Rehydration results in significant recovery of APLT in erythrocytes previously dehydrated in vitro, but not in sickle erythrocytes dehydrated in vivo Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 APLT activities in healthy and sickle erythrocytes, hydrated or dehydrated, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
APLT
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane, and phospholipid scramblase, PLSCR, equilibrates phospholipids across the membrane Homo sapiens
physiological function aminophospholipid translocase returns externalized phosphatidylserine to the inner membrane, and phospholipid scramblase, PLSCR, equilibrates phospholipids across the membrane. APLT inhibition and PLSCR activation appear to be important for phosphatidylserine externalization Homo sapiens