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Literature summary for 7.6.2.1 extracted from

  • Muthusamy, B.P.; Raychaudhuri, S.; Natarajan, P.; Abe, F.; Liu, K.; Prinz, W.A.; Graham, T.R.
    Control of protein and sterol trafficking by antagonistic activities of a P4-ATPase and oxysterol binding protein homologue (2009), Mol. Biol. Cell, 20, 2920-2931.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Application

Application Comment Organism
additional information Drs2p deficiency causes a markedly increased rate of cholesterol transport from the plasma membrane to the endoplasmic reticulum and redistribution of endogenous ergosterol to intracellular membranes Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
Kes1p Kes1p represses the flippase activity of Drs2p in trans-Golgi network membranes Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane trans-Golgi network membranes Saccharomyces cerevisiae 16020
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylethanolamine/out
-
 Saccharomyces cerevisiae ADP + phosphate + phosphatidylethanolamine/in
-
 ?
ATP + H2O + phosphatidylserine/out
-
 Saccharomyces cerevisiae ADP + phosphate + phosphatidylserine/in
-
 ?

Synonyms

Synonyms Comment Organism
Drs2-dependent phosphatidylserine translocase
-
 Saccharomyces cerevisiae
Drs2p
-
 Saccharomyces cerevisiae
flippase
-
 Saccharomyces cerevisiae
P4-ATPase
-
 Saccharomyces cerevisiae
type IV P-type ATPase
-
 Saccharomyces cerevisiae