Cloned (Comment) | Organism |
---|---|
PLSCR1 DNA and amino acid sequence determination and analysis, co-expression of PLSCR1 as maltose-binding-protein fusion protein and GST-tagged DNA topoisomerase II in Escherichia coli strain BL21(DE3), expression of a human B lymphocyte library, ATCC 87003, and DNA topoisomerase II from HeLa cells in the yeast two hybrid system, interaction analysis, identification of PLSCR1 as binding protein, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | although predominantly a plasma membrane protein, PLSCR1 can also be imported into the nucleus, nuclear co-localization of PLSCR1 and DNA topoisomerase IIalpha | Homo sapiens | 5634 | - |
plasma membrane | although predominantly a plasma membrane protein, PLSCR1 can also be imported into the nucleus | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme interacts with the alpha and beta isozymes of DNA topoisomerase II binding to a specific binding site on the topo isozymes, DNA topoisomerase II isozyme alpha residues 1432-1441 are essential for binding to PLSCR1, the interaction can be inhibited by a synthetic peptide corresponding to DNA topoisomerase II isozyme alpha amino acids 1430-1441, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipid scramblase 1 | - |
Homo sapiens |
PLSCR1 | - |
Homo sapiens |