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Literature summary for 7.6.2.1 extracted from

  • Wyles, J.P.; Wu, Z.; Mirski, S.E.; Cole, S.P.
    Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1 (2007), Nucleic Acids Res., 35, 4076-4085.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
PLSCR1 DNA and amino acid sequence determination and analysis, co-expression of PLSCR1 as maltose-binding-protein fusion protein and GST-tagged DNA topoisomerase II in Escherichia coli strain BL21(DE3), expression of a human B lymphocyte library, ATCC 87003, and DNA topoisomerase II from HeLa cells in the yeast two hybrid system, interaction analysis, identification of PLSCR1 as binding protein, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus although predominantly a plasma membrane protein, PLSCR1 can also be imported into the nucleus, nuclear co-localization of PLSCR1 and DNA topoisomerase IIalpha Homo sapiens 5634
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plasma membrane although predominantly a plasma membrane protein, PLSCR1 can also be imported into the nucleus Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLSCR1 is involved in phosphatidylserine externalization across the plasma membrane, the recombinant PLSCR1 stimulates the decatenation activity of DNA topoisomerase II isozyme alpha, overview Homo sapiens ?
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?
additional information the enzyme interacts with the alpha and beta isozymes of DNA topoisomerase II binding to a specific binding site on the topo isozymes, DNA topoisomerase II isozyme alpha residues 1432-1441 are essential for binding to PLSCR1, the interaction can be inhibited by a synthetic peptide corresponding to DNA topoisomerase II isozyme alpha amino acids 1430-1441, overview Homo sapiens ?
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Synonyms

Synonyms Comment Organism
phospholipid scramblase 1
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Homo sapiens
PLSCR1
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Homo sapiens