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Literature summary for 7.6.2.1 extracted from
- Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites (2006), J. Biol. Chem., 281, 23766-23775.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | LdMT and LdRos3 | Leishmania donovani | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + miltefosine/in | Leishmania donovani | LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania | ADP + phosphate + miltefosine/out | - |
? |  |
| ATP + H2O + phospholipid/in | Leishmania donovani | LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required | ADP + phosphate + phospholipid/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + miltefosine/in | - |
Leishmania donovani | ADP + phosphate + miltefosine/out | - |
? | |
| ATP + H2O + miltefosine/in | LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania | Leishmania donovani | ADP + phosphate + miltefosine/out | - |
? | |
| ATP + H2O + phospholipid/in | - |
Leishmania donovani | ADP + phosphate + phospholipid/out | - |
? | |
| ATP + H2O + phospholipid/in | LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required | Leishmania donovani | ADP + phosphate + phospholipid/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flippase | - |
Leishmania donovani |
| LdMT | - |
Leishmania donovani |
| LdRos3 | beta-subunit of LdMT | Leishmania donovani |
| miltefosine transporter | - |
Leishmania donovani |
| More | the enzyme belongs to the P-type ATPases, LdRos3 belongs to the CDC50/Lem3 family, proposed as likely beta-subunits for P4-ATPases | Leishmania donovani |
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Release 2023.1 (January 2023)
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