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Literature summary for 7.6.2.1 extracted from
- Identification of an erythroid ATP-dependent aminophospholipid transporter (2006), Br. J. Haematol., 133, 436-438.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell membrane | - |
Mus musculus | - |
- |
| chromaffin granule | - |
Mus musculus | 42583 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine/in | Mus musculus | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology | ADP + phosphate + phosphatidylserine/out | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice, two isozymes Atp8a1 and flippase | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| erythroblast | - |
Mus musculus | - |
| erythrocyte | - |
Mus musculus | - |
| erythroid progenitor cell | - |
Mus musculus | - |
| Friend erythroleukemia cell line | - |
Mus musculus | - |
| additional information | distribution of isozyme expression in different cells, overview | Mus musculus | - |
| reticulocyte | expression analysis of isozymes Atp8a1 and flippase in reticulocytes, overview | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane, exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology | Mus musculus | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry | Mus musculus | ADP + phosphate + phosphatidylserine/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid translocase | - |
Mus musculus |
| ATP8A1 | - |
Mus musculus |
| erythroid ATP-dependent aminophospholipid transporter | - |
Mus musculus |
| flippase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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