BRENDA - Enzyme Database
show all sequences of 7.6.2.1

Lipid specific activation of the murine P4-ATPase Atp8a1 (ATPase II)

Paterson, J.K.; Renkema, K.; Burden, L.; Halleck, M.S.; Schlegel, R.A.; Williamson, P.; Daleke, D.L.; Biochemistry 45, 5367-5376 (2006)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
the secretory granule Atp8a1 is activated by phospholipids binding to a specific site whose properties (PS selectivity, dependence upon glycerol but not serine, stereochemistry, and vanadate sensitivity) are similar to, but distinct from, the properties of the substrate binding site of the plasma membrane flippase, no activation by N-methylphosphatidylserine, phosphatidylserine-O-methyl ester, lysophosphatidylserine, glycerophosphoserine, and phosphoserine, Atp8a1 activities are insensitive to the stereochemistry of the serine headgroup of activating phospholipid
Mus musculus
phosphatidylethanolamine
slight activation
Mus musculus
phosphatidylglycerol
slight activation
Mus musculus
phosphatidylhomoserine
slight activation
Mus musculus
phosphatidylhydroxypropionate
slight activation
Mus musculus
phosphatidylserine
2.1fold activation, Atp8a1 is activated only by the naturally occurring sn-1,2-glycerol isomer of PS and not the sn-2,3-glycerol stereoisomer
Mus musculus
Cloned(Commentary)
Commentary
Organism
expression of His-tagged Atp8a1 in Spodoptera frugiperda Sf21 cells using the baculovirus transfection system
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Ca2+
-
Mus musculus
sulfhydryl reagents
-
Mus musculus
vanadate
-
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
-
Mus musculus
5886
-
secretory granule
-
Mus musculus
30141
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
120000
-
x * 120000, recombinant His-tagged Atp8a1, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + H2O + phosphatidylserine/in
Mus musculus
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
ADP + phosphate + phosphatidylserine/out
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant His-tagged Atp8a1 from Spodoptera frugiperda Sf21 cells by microsome preparation and nickel affinity chromatography
Mus musculus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3
-
Atp8a1 in Sf21 cell lysate, in absence of phosphatidylserine
Mus musculus
4.9
-
Atp8a1 in Sf21 cell lysate, in presence of phosphatidylserine
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + phosphatidylserine/in
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
685075
Mus musculus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry
685075
Mus musculus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 120000, recombinant His-tagged Atp8a1, SDS-PAGE
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
the secretory granule Atp8a1 is activated by phospholipids binding to a specific site whose properties (PS selectivity, dependence upon glycerol but not serine, stereochemistry, and vanadate sensitivity) are similar to, but distinct from, the properties of the substrate binding site of the plasma membrane flippase, no activation by N-methylphosphatidylserine, phosphatidylserine-O-methyl ester, lysophosphatidylserine, glycerophosphoserine, and phosphoserine, Atp8a1 activities are insensitive to the stereochemistry of the serine headgroup of activating phospholipid
Mus musculus
phosphatidylethanolamine
slight activation
Mus musculus
phosphatidylglycerol
slight activation
Mus musculus
phosphatidylhomoserine
slight activation
Mus musculus
phosphatidylhydroxypropionate
slight activation
Mus musculus
phosphatidylserine
2.1fold activation, Atp8a1 is activated only by the naturally occurring sn-1,2-glycerol isomer of PS and not the sn-2,3-glycerol stereoisomer
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of His-tagged Atp8a1 in Spodoptera frugiperda Sf21 cells using the baculovirus transfection system
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Ca2+
-
Mus musculus
sulfhydryl reagents
-
Mus musculus
vanadate
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
-
Mus musculus
5886
-
secretory granule
-
Mus musculus
30141
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
120000
-
x * 120000, recombinant His-tagged Atp8a1, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + H2O + phosphatidylserine/in
Mus musculus
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
ADP + phosphate + phosphatidylserine/out
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His-tagged Atp8a1 from Spodoptera frugiperda Sf21 cells by microsome preparation and nickel affinity chromatography
Mus musculus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3
-
Atp8a1 in Sf21 cell lysate, in absence of phosphatidylserine
Mus musculus
4.9
-
Atp8a1 in Sf21 cell lysate, in presence of phosphatidylserine
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + phosphatidylserine/in
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry in the plasma membrane and secretory vesicles
685075
Mus musculus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
ATP + H2O + phosphatidylserine/in
selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the cell membrane to maintain lipid asymmetry
685075
Mus musculus
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 120000, recombinant His-tagged Atp8a1, SDS-PAGE
Mus musculus
Other publictions for EC 7.6.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747035
Perandres-Lopez
Functional role of highly con ...
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Biochem. J.
475
887-899
2018
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3
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747650
Takada
Phospholipid-flipping activit ...
Homo sapiens
EMBO J.
37
pii: e97705
2018
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1
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1
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1
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1
1
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749361
Wang
Proteomic analysis and functi ...
Mus musculus
Sci. Rep.
8
10795
2018
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2
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5
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1
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10
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11
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5
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30
1
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20
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50
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10
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10
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31
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30
10
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747894
Yamamoto
Cfs1p, a novel membrane prote ...
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2
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2
2
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748628
Chalat
C-terminus of the P4-ATPase A ...
Bos taurus
Mol. Biol. Cell
28
452-462
2017
2
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1
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2
-
1
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1
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1
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2
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1
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1
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748744
Takatsu
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Homo sapiens
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8
1423
2017
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1
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1
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747188
van der Mark
The phospholipid flippase ATP ...
Homo sapiens
Biochim. Biophys. Acta
1863
2280-2288
2016
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3
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6
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6
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2
2
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747611
Roland
Decoding P4-ATPase substrate ...
Saccharomyces cerevisiae
Crit. Rev. Biochem. Mol. Biol.
51
513-527
2016
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1
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3
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1
1
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748627
Tanaka
The phospholipid flippase ATP ...
Homo sapiens
Mol. Biol. Cell
27
3883-3893
2016
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3
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1
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3
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1
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1
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1
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2
2
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748976
Botella
ALA10, a phospholipid flippas ...
Arabidopsis thaliana
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170
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2016
-
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3
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1
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3
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1
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1
1
1
1
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749181
Roland
Directed evolution of a sphin ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
113
E4460-E4466
2016
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12
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1
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1
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2
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6
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12
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6
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733726
Lee
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Homo sapiens
EMBO J.
34
669-688
2015
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1
2
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734307
Naito
Phospholipid flippase ATP10A t ...
Homo sapiens
J. Biol. Chem.
290
15004-15017
2015
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2
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4
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3
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1
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1
1
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734314
Ansari
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Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
23110-23123
2015
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2
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6
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2
4
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747769
Vestergaard
Specific mutations in mammali ...
Bos taurus
FEBS Lett.
589
3908-3914
2015
-
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1
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14
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1
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14
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1
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748170
Takatsu
ATP9B, a P4-ATPase (a putativ ...
Saccharomyces cerevisiae
J. Biol. Chem.
286
38159-38167
2015
-
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1
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1
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1
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3
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749049
Yamagami
Inositol depletion restores v ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YEF473
PLoS ONE
10
e0120108
2015
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2
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3
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2
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8
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1
1
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734287
Takatsu
Phospholipid flippase activiti ...
Homo sapiens
J. Biol. Chem.
289
33543-33556
2014
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2
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1
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6
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1
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8
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5
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1
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1
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8
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1
2
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735189
Vestergaard
Critical roles of isoleucine-3 ...
Bos taurus
Proc. Natl. Acad. Sci. USA
111
E1334-E1343
2014
1
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22
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34
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2
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4
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1
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22
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2
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Sanyal
Distinct flippases translocate ...
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Poulsen
Flippases: still more question ...
Saccharomyces cerevisiae
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2008
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-
-
-
-
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-
697594
Masuda
Study of oxidized lipids as en ...
Homo sapiens
Drug Metab. Lett.
2
238-244
2008
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1
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1
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1
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6
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1
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1
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6
-
-
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-
-
-
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-
700292
Barta
Effects of monoglycerides on P ...
Homo sapiens
Mol. Pharm.
5
863-875
2008
-
-
-
-
-
-
2
-
-
-
1
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1
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2
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2
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2
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1
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2
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2
-
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700953
Ruiz
Bioinformatics identification ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
105
15553-15557
2008
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-
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1
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1
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4
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2
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684674
Sahu
Phospholipid scramblases: an o ...
Caenorhabditis elegans, Homo sapiens, Mus musculus
Arch. Biochem. Biophys.
462
103-114
2007
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-
3
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1
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-
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9
3
2
7
-
7
-
4
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6
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-
14
2
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7
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1
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15
7
3
7
-
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9
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-
14
-
-
14
3
-
-
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-
-
-
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-
-
-
685132
Smriti
ATP-dependent transport of pho ...
Homo sapiens
Biochemistry
46
2249-2259
2007
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-
-
-
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-
2
-
1
1
-
2
-
2
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1
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8
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1
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1
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2
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1
1
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2
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1
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8
-
1
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-
-
1
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-
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686022
Razmara
Glycoprotein IIb/IIIa blockade ...
Homo sapiens
Cell. Mol. Life Sci.
64
999-1008
2007
2
-
-
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1
1
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2
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1
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1
1
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2
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1
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2
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1
1
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1
1
-
2
-
1
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-
1
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-
-
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-
-
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-
686247
Zuellig
Aminophospholipid translocase ...
Caenorhabditis elegans
Curr. Biol.
17
994-999
2007
-
1
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-
1
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1
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1
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3
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2
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1
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1
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1
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1
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-
2
-
-
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-
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686385
Camberg
Synergistic stimulation of Eps ...
Vibrio cholerae
EMBO J.
26
19-27
2007
2
-
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1
1
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1
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1
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2
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1
1
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1
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-
686682
Regev
Modulation of P-glycoprotein-m ...
Homo sapiens
FEBS J.
274
6204-6214
2007
1
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1
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1
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2
1
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1
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1
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4
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1
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1
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1
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1
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1
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2
1
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1
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4
-
1
-
-
-
1
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-
-
-
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-
-
-
-
687006
Morita
Bile salt-dependent efflux of ...
Homo sapiens
Hepatology
46
188-199
2007
4
-
1
-
2
-
1
-
2
1
1
1
-
2
-
1
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3
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2
1
1
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1
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4
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1
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2
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1
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2
1
1
1
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1
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3
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687552
Papadopulos
Flippase activity detected wit ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae sec61
J. Biol. Chem.
282
15559-15568
2007
-
-
-
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1
2
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4
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4
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1
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1
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1
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10
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1
2
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4
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1
1
-
1
-
10
-
-
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-
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-
-
-
-
-
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687558
Stevens
The proton electrochemical gra ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae LMY65
J. Biol. Chem.
282
17563-17567
2007
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2
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2
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3
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1
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4
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2
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2
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1
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4
-
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-
-
-
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-
-
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687676
Tyurina
Nitrosative stress inhibits th ...
Homo sapiens
J. Biol. Chem.
282
8498-8509
2007
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2
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1
3
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1
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1
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1
1
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2
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1
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1
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2
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1
3
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1
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1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688706
Leung
Persistence of procoagulant su ...
Homo sapiens
J. Thromb. Haemost.
5
560-570
2007
-
-
-
-
-
-
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1
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1
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2
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1
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2
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1
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1
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1
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1
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1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688902
Furuta
Endocytic recycling in yeast i ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
295-312
2007
-
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1
-
1
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2
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2
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2
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4
1
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1
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1
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2
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2
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-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688907
Liu
Yeast P4-ATPases Drs2p and Dnf ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
487-500
2007
-
-
1
-
1
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-
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4
-
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1
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2
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1
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-
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2
1
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1
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1
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4
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1
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1
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-
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689125
Wang
C. elegans mitochondrial facto ...
Caenorhabditis elegans
Nat. Cell Biol.
9
541-549
2007
1
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1
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-
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2
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1
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2
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-
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1
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1
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1
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-
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1
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2
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1
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689249
Wyles
Nuclear interactions of topois ...
Homo sapiens
Nucleic Acids Res.
35
4076-4085
2007
-
-
1
-
-
-
-
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2
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1
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3
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-
-
-
-
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2
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1
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-
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2
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1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667438
Noji
Mutational analysis of the Lem ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
344
323-331
2006
-
-
-
-
1
-
-
-
3
1
-
1
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2
-
-
-
-
-
-
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4
-
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-
-
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-
-
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-
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-
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1
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-
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3
1
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1
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668247
Devaux
Proteins involved in lipid tra ...
Bos taurus, Homo sapiens, Leishmania infantum, Rattus norvegicus, Saccharomyces cerevisiae
Chem. Phys. Lipids
141
119-132
2006
-
-
-
-
1
1
3
-
11
5
1
14
-
5
-
-
2
-
-
6
-
-
21
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
11
5
1
14
-
-
-
2
-
6
-
-
21
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671002
Verhoeven
Prolonged storage of red blood ...
Homo sapiens
Vox Sang.
91
244-251
2006
1
-
-
-
-
-
1
-
1
2
-
3
-
1
-
-
-
-
-
1
-
2
5
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
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-
1
2
-
3
-
-
-
-
-
1
-
2
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
685075
Paterson
Lipid specific activation of t ...
Mus musculus
Biochemistry
45
5367-5376
2006
6
-
1
-
-
-
3
-
2
1
1
1
-
4
-
-
1
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
3
-
-
2
1
1
1
-
-
-
1
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685854
Soupene
Identification of an erythroid ...
Mus musculus
Br. J. Haematol.
133
436-438
2006
-
-
-
-
-
-
-
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2
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1
-
2
-
-
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-
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7
-
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2
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-
-
-
-
-
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-
-
-
-
-
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2
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1
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-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687516
Perez-Victoria
Phospholipid translocation and ...
Leishmania donovani
J. Biol. Chem.
281
23766-23775
2006
-
-
-
-
-
-
-
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1
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2
-
4
-
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-
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4
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-
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1
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2
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-
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688899
Alder-Baerens
Loss of P4 ATPases Drs2p and D ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae EHY227
Mol. Biol. Cell
17
1632-1642
2006
-
-
-
-
1
-
-
-
4
1
-
7
-
3
-
-
-
-
-
-
-
-
13
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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-
4
1
-
7
-
-
-
-
-
-
-
-
13
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
690150
Chen
Roles for the Drs2p-Cdc50p com ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CCY 2811
Traffic
7
1503-1517
2006
-
-
1
-
1
-
-
-
4
-
-
2
-
3
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
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-
4
-
-
2
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668223
Wolfs
Activated scramblase and inhib ...
Homo sapiens
Cell. Mol. Life Sci.
62
1514-1525
2005
1
-
-
-
-
-
3
-
1
1
-
2
-
1
-
-
-
-
-
1
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
1
1
-
2
-
-
-
-
-
1
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
669094
Camberg
Molecular analysis of the Vibr ...
Homo sapiens
J. Bacteriol.
187
249-256
2005
-
-
-
-
-
-
-
-
1
1
-
2
-
3
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
1
-
2
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670455
Vishwakarma
New fluorescent probes reveal ...
Rattus norvegicus
Org. Biomol. Chem.
3
1275-1283
2005
-
-
-
-
-
-
-
1
1
-
-
1
-
3
-
-
-
-
-
1
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7
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
1
-
-
7
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
655136
Castegna
Modulation of phospholipid asy ...
Meriones unguiculatus
Brain Res.
1004
193-197
2004
-
-
-
-
-
-
3
-
2
-
-
1
-
1
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-
-
-
-
-
-
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1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
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3
-
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2
-
-
1
-
-
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656761
Saito
Cdc50p, a protein required for ...
Saccharomyces cerevisiae
Mol. Biol. Cell
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