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Literature summary for 7.6.2.1 extracted from
- Proteins involved in lipid translocation in eukaryotic cells (2006), Chem. Phys. Lipids, 141, 119-132.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | simultaneous inactivation of Dnf2p and Dnf1p abolishes the ATP-dependent influx of phosphatidylserine and phosphatidylethanolamine into the cell | Saccharomyces cerevisiae |
General Stability
| General Stability | Organism |
|---|---|
| the enzyme is very instable and rapidly degenerated during purification | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| NEM | - |
Homo sapiens | |
| vanadate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell membrane | - |
Homo sapiens | - |
- |
| cell membrane | - |
Saccharomyces cerevisiae | - |
- |
| cell membrane | - |
Bos taurus | - |
- |
| cell membrane | - |
Leishmania infantum | - |
- |
| endoplasmic reticulum | Neo1p | Saccharomyces cerevisiae | 5783 | - |
| endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
| endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
| endosome | Neo1p | Saccharomyces cerevisiae | 5768 | - |
| Golgi membrane | Drs2p and Dnf3p | Saccharomyces cerevisiae | 139 | - |
| additional information | chromaffine granules | Bos taurus | - |
- |
| plasma membrane | Dnf1p and Dnf2p | Saccharomyces cerevisiae | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | scramblase activity is dependent on Ca2+ | Homo sapiens | |
| Mg2+ | dependent on | Homo sapiens | |
| Mg2+ | dependent on | Saccharomyces cerevisiae | |
| Mg2+ | dependent on | Bos taurus | |
| Mg2+ | dependent on | Leishmania infantum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37000 | - |
x * 37000, scramblase | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylethanolamine/out | Homo sapiens | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | Saccharomyces cerevisiae | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | Bos taurus | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | Leishmania infantum | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | Homo sapiens | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | Saccharomyces cerevisiae | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | Bos taurus | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | Leishmania infantum | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | ADP + phosphate + phosphatidylserine/in | - |
? | |
| additional information | Homo sapiens | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | ? | - |
? | |
| additional information | Bos taurus | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | ? | - |
? | |
| additional information | Leishmania infantum | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane, especially Neo1p is important, Drs2p is involved in vesicle formation in the Golgi and thus influences the plasma membrane distribution of aminophospholipids despite its localization the Golgi membrane, mechanism | ? | - |
? | |
| phospholipid/in | Homo sapiens | unspecific bidirectional transmembrane transport of phospholipids | phospholipid/out | - |
r | |
| phospholipid/in | Rattus norvegicus | unspecific bidirectional transmembrane transport of phospholipids | phospholipid/out | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Leishmania infantum | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
five P-type ATPases involved inlipid transport | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ATP8A1 from chromaffin granules | Bos taurus |
| partially from erythrocytes | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
| erythrocyte | - |
Homo sapiens | - |
| fibroblast | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| osteoblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylethanolamine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Homo sapiens | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Saccharomyces cerevisiae | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Bos taurus | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylethanolamine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Leishmania infantum | ADP + phosphate + phosphatidylethanolamine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Homo sapiens | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Saccharomyces cerevisiae | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Bos taurus | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane | Leishmania infantum | ADP + phosphate + phosphatidylserine/in | - |
? | |
| ATP + H2O + phosphatidylserine/out | transport from the exoplasmic to the cytosolic leaflet of the plasma membrane, and from the lumenal side of granules to the external side | Bos taurus | ADP + phosphate + phosphatidylserine/in | - |
? | |
| additional information | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | Bos taurus | ? | - |
? | |
| additional information | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane | Leishmania infantum | ? | - |
? | |
| additional information | the enzyme is a P-type ATPase involved in regulation of the lipid asymmetry of the cell membrane, especially Neo1p is important, Drs2p is involved in vesicle formation in the Golgi and thus influences the plasma membrane distribution of aminophospholipids despite its localization the Golgi membrane, mechanism | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme depends on ATP | Homo sapiens | ? | - |
? | |
| additional information | the enzyme depends on ATP | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme depends on ATP | Bos taurus | ? | - |
? | |
| additional information | the enzyme depends on ATP | Leishmania infantum | ? | - |
? | |
| additional information | the enzyme is independent of ATP or energy supply | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is independent of ATP or energy supply | Rattus norvegicus | ? | - |
? | |
| phospholipid/in | unspecific bidirectional transmembrane transport of phospholipids | Homo sapiens | phospholipid/out | - |
r | |
| phospholipid/in | unspecific bidirectional transmembrane transport of phospholipids | Rattus norvegicus | phospholipid/out | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 37000, scramblase | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid translocase | - |
Homo sapiens |
| aminophospholipid translocase | - |
Saccharomyces cerevisiae |
| aminophospholipid translocase | - |
Bos taurus |
| aminophospholipid translocase | - |
Leishmania infantum |
| APLT | - |
Homo sapiens |
| APLT | - |
Saccharomyces cerevisiae |
| APLT | - |
Bos taurus |
| APLT | - |
Leishmania infantum |
| ATP-independent flippase | - |
Homo sapiens |
| ATP-independent flippase | - |
Rattus norvegicus |
| ATP8A1 | - |
Bos taurus |
| ATPase II | - |
Homo sapiens |
| ATPase II | - |
Saccharomyces cerevisiae |
| ATPase II | - |
Bos taurus |
| Dnf1p | - |
Saccharomyces cerevisiae |
| Dnf2p | - |
Saccharomyces cerevisiae |
| Dnf3p | - |
Saccharomyces cerevisiae |
| Drs2p | - |
Saccharomyces cerevisiae |
| More | the enzyme is a P-type ATPase | Bos taurus |
| More | the enzyme is a P-type ATPase | Leishmania infantum |
| More | the enzyme is a P-type ATPase, while the outward translocating floppase activity is performed by an ABC ATPase | Homo sapiens |
| More | the enzyme is a P-type ATPase, while the outward translocating floppase activity is performed by an ABC ATPase | Saccharomyces cerevisiae |
| Neo1p | - |
Saccharomyces cerevisiae |
| scramblase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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