Literature summary for 7.6.2.1 extracted from

Wolfs, J.L.; Comfurius, P.; Rasmussen, J.T.; Keuren, J.F.; Lindhout, T.; Zwaal, R.F.; Bevers, E.M.
Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction (2005), Cell. Mol. Life Sci., 62, 1514-1525.

Search for more literature for 7.6.2.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Ca2+-stimulated phosphatidylserine exposure at the surface activates the enzyme	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	-	Homo sapiens
additional information	no inhibition by NEM	Homo sapiens
NEM	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	preparation of microparticles for in vitro assay	Homo sapiens	5886	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + phosphatidylserine/out	Homo sapiens	transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview	ADP + phosphate + phosphatidylserine/in	-	?
phosphatidylserine/out	Homo sapiens	bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview	phosphatidylserine/in	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	the enzyme is only active in the platelet fraction which does expose phosphatidylserine, and is inactive int he platelet fraction not exposing phosphatidylserine, overview	Homo sapiens	-
blood platelet	the enzyme occurs only in the platelet fraction which does not expose phosphatidylserine	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + phosphatidylserine/out	transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview	Homo sapiens	ADP + phosphate + phosphatidylserine/in	-	?
ATP + H2O + phosphatidylserine/out	7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the external leaflet of the membrane to the inner leaflet	Homo sapiens	ADP + phosphate + phosphatidylserine/in	-	?
additional information	the enzyme does not require energy supply by ATP hydrolysis	Homo sapiens	?	-	?
phosphatidylserine/out	bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview	Homo sapiens	phosphatidylserine/in	-	r
phosphatidylserine/out	7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, bidirectional transport	Homo sapiens	phosphatidylserine/in	-	r

Synonyms

Synonyms	Comment	Organism
aminophospholipid scramblase	-	Homo sapiens
aminophospholipid translocase	-	Homo sapiens
scramblase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)