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Literature summary for 7.6.2.1 extracted from
- Functional cloning of the miltefosine transporter: A novel P-type phospholipid translocase from Leishmania involved in drug resistance (2003), J. Biol. Chem., 278, 49965-49971.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| LdMT is cloned by rescuing the resistance phenotype of the M-40 R cell line overexpression in Leishmania tarentolae | Leishmania donovani |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Leishmania donovani | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Leishmania donovani | the enzyme is directly involved in miltefosine uptake in eukaryotic cells | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is directly involved in miltefosine uptake in eukaryotic cells | Leishmania donovani | ? | - |
? | |
| additional information | the enzyme is able to promote the translocalisation of aminophospholipids and glycerophosphocholine molecules such as NBD-phosphatidylcholine and edelfosine and non glycerol based alkylphosphocholine miltefosin | Leishmania donovani | ? | - |
? | |
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