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Literature summary for 7.6.2.1 extracted from

  • Beleznay, Z.; Zachowski, A.; Devaux, P.F.; Ott, P.
    Characterization of the correlation between ATP-dependent aminophospholipid translocation and Mg2+-ATPase activity in red blood cell membranes (1997), Eur. J. Biochem., 243, 58-65.
    View publication on PubMed
Search for more literature for 7.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
elaiophylin partial inhibition of Mg+-ATPase activity, translocation of phosphatidylserine is almost completely abolished Homo sapiens
eosin Y almost complete inhibition of both Mg2+-ATPase activity and translocation Homo sapiens
suramin competitive inhibitor of ATP towards both Mg2+-ATPase activity and aminophospholipid translocation. Inhibition of translocation occurs at higher inhibitor concentration than the inhibition of Mg2+-ATPase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.211
-
 ATP phosphatase activity Homo sapiens
0.225
-
 ATP phosphatidylserine translocase activity Homo sapiens
1.03
-
 acetyl phosphate phosphatase activity Homo sapiens
1.17
-
 p-nitrophenyl phosphate phosphatase activity, detection of p-nitrophenolate formation from trichloroacetic acid precipitates Homo sapiens
1.31
-
 acetyl phosphate phosphatidylserine translocase activity Homo sapiens
1.39
-
 p-nitrophenyl phosphate phosphatidylserine translocase activity Homo sapiens
1.46
-
 p-nitrophenyl phosphate phosphatase activity, continous detection of p-nitrophenolate formation in ghost at neutral pH Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2] P-type ATPase Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl phosphate + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens acetate + phosphate
-
 ?
ATP + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens ADP + phosphate
-
 ?
p-nitrophenyl phosphate + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens p-nitrophenol + phosphate
-
 ?