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Literature summary for 7.5.2.1 extracted from

  • Grote, M.; Polyhach, Y.; Jeschke, G.; Steinhoff, H.J.; Schneider, E.; Bordignon, E.
    Transmembrane signaling in the maltose ABC transporter MALFGK2-E: The periplasmic MALF-P2 loop communicates substrate availability to the ATP-bound malk dimer (2009), J. Biol. Chem., 284, 17521-17526.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.5.2.1

Protein Variants

Protein Variants Comment Organism
C40S/S83C site-directed mutagenesis, the mutant shows altered subunit interactions in the maltose ABC transporter MALFGK2-E Escherichia coli
additional information the MalK2 ATP hydrolysis cycle does not induce MalF-P2 loop rearrangements in the absence of MalE Escherichia coli
S205C/S252C site-directed mutagenesis, the mutant shows altered subunit interactions in the maltose ABC transporter MALFGK2-E Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane extracytoplasmic anchoring of the substrate binding protein Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + maltose/out Escherichia coli extracytoplasmic anchoring of the substrate binding protein, the receptor, is emerging as key determinant for the structural rearrangements in the cytoplasmically exposed ATP-binding cassette domains and in the transmembrane gates during the nucleotide cycle, molecular mechanism, overview ADP + phosphate + maltose/in
-
 ?
additional information Escherichia coli concomitantly with the three conformations of the ATP-binding cassette MalK2, three functionally relevant conformations are found also in the periplasmic MalF-P2 loop, strictly dependent on cytoplasmic nucleotide-binding and periplasmic docking of liganded MalE to MalFG, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + maltose/out
-
 Escherichia coli ADP + phosphate + maltose/in
-
 ?
ATP + H2O + maltose/out extracytoplasmic anchoring of the substrate binding protein, the receptor, is emerging as key determinant for the structural rearrangements in the cytoplasmically exposed ATP-binding cassette domains and in the transmembrane gates during the nucleotide cycle, molecular mechanism, overview Escherichia coli ADP + phosphate + maltose/in
-
 ?
additional information concomitantly with the three conformations of the ATP-binding cassette MalK2, three functionally relevant conformations are found also in the periplasmic MalF-P2 loop, strictly dependent on cytoplasmic nucleotide-binding and periplasmic docking of liganded MalE to MalFG, overview Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
maltose ABC transporter MALFGK2-E
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli