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Literature summary for 7.5.2.1 extracted from

  • Reich-Slotky, R.; Panagiotidis, C.; Reyes, M.; Shuman, H.A.
    The detergent-soluble maltose transporter is activated by maltose binding protein and verapamil (2000), J. Bacteriol., 182, 993-1000.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.5.2.1

Activating Compound

Activating Compound Comment Organism Structure
maltose-binding protein stimulates detergent-soluble maltose transporter, does not change the affinity of the complex for ATP but does increase the maximal rate of ATP hydrolysis Escherichia coli
verapamil stimulates detergent-soluble maltose transporter, increases ATPase activity and lowers affinity for ATP Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
NaN3 FGK2 complex Escherichia coli
p-chloromercuriphenyl sulfonic acid FGK2 complex Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.143
-
 ATP in presence of 0.05 mM maltose binding protein Escherichia coli
0.154
-
 ATP in absence of maltose binding protein Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK Escherichia coli
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + maltose/out Escherichia coli the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK. In addition malK participates in two different regulatory pathways which modulate mal gene expression and MalFGK transport activity ADP + phosphate + maltose/in
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
with the aid of a glutathione S-transferase molecular tag Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + maltose/out
-
 Escherichia coli ADP + phosphate + maltose/in
-
 ?
ATP + H2O + maltose/out the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK. In addition malK participates in two different regulatory pathways which modulate mal gene expression and MalFGK transport activity Escherichia coli ADP + phosphate + maltose/in
-
 ?