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Literature summary for 7.4.2.7 extracted from

  • Proff, C.; Kölling, R.
    Functional asymmetry of the two nucleotide binding domains in the ABC transporter Ste6 (2001), Mol. Gen. Genet., 264, 883-893.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A517P mutant enzyme shows 0.01% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
E439K mutant enzyme shows 0.01% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
E531K/V533I mutant enzyme shows 0.75% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
G1087D mutant enzyme is completely defective for mating Saccharomyces cerevisiae
G1092E mutant enzyme is completely defective for mating Saccharomyces cerevisiae
G320D mutant enzyme shows 5.5% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
G320V mutant enzyme shows 6% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
G38D mutant enzyme is completly defective for mating, mutant enzyme does not accumulate in plasma membrane fraction Saccharomyces cerevisiae
G38N mutant enzyme shows 0.06-0.01% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
G392E mutant enzyme is completely defective for mating Saccharomyces cerevisiae
G392K mutant enzyme is completely defective for mating Saccharomyces cerevisiae
G397D mutant enzyme is completely defective for mating Saccharomyces cerevisiae
G397N mutant enzyme shows 1.7% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
P525L mutant enzyme shows 7% of the mating efficiency of the wild-type enzyme at 25°C, 0.06% at 30°C and is defective for mating at 37°C Saccharomyces cerevisiae
R833K/R941H mutant enzyme shows 1.9% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
S507N mutant enzyme shows 0.5-0.85% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae
S507N/G508S/G509R mutant enzyme is completely defective for mating Saccharomyces cerevisiae
S632F/Q633STOP mutant enzyme shows 1.8% of the mating efficiency of the wild-type enzyme Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane wild-type enzyme Saccharomyces cerevisiae 5886
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P12866
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + alpha-factor/in
-
Saccharomyces cerevisiae ADP + phosphate + alpha-factor/out
-
?

Synonyms

Synonyms Comment Organism
ABC transporter Ste6
-
Saccharomyces cerevisiae
Ste6
-
Saccharomyces cerevisiae