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Literature summary for 7.4.2.6 extracted from

  • Hopfe, M.; Henrich, B.
    OppA, the ecto-ATPase of Mycoplasma hominis induces ATP release and cell death in HeLa cells (2008), BMC Microbiol., 8, 55.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.6

Inhibitors

Inhibitors Comment Organism Structure
4',4'-diisothiocyanostilbene-2,2'-disulfonate i.e. DIDS Mycoplasma hominis
suramin
-
 Mycoplasma hominis
Trypsin tryptic digestion of OppA was protected by ATP and ADP but not by GTP or CTP Mycoplasma hominis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface more than 80% of the surface-localised ATPase activity of Mycoplasma hominis is derived from OppA, implicating that OppA is the main ATPase on the surface of mycoplasma cells Mycoplasma hominis 9986
-
membrane
-
 Mycoplasma hominis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + olipopeptide/out Mycoplasma hominis
-
 ADP + phosphate + oligopeptide/in
-
 ?
additional information Mycoplasma hominis the ecto-ATPase OppA, the surface-localized substrate-binding domain of the oligopeptide permease, of Mycoplasma hominis induces ATP release and both apoptotic and necrotic cell death in HeLa cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycoplasma hominis
-
 cultured in HeLa cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + olipopeptide/out
-
 Mycoplasma hominis ADP + phosphate + oligopeptide/in
-
 ?
additional information the ecto-ATPase OppA, the surface-localized substrate-binding domain of the oligopeptide permease, of Mycoplasma hominis induces ATP release and both apoptotic and necrotic cell death in HeLa cells, overview Mycoplasma hominis ?
-
 ?
additional information OppA binds ATP and ADP but not GTP Mycoplasma hominis ?
-
 ?

Synonyms

Synonyms Comment Organism
ecto-ATPase
-
 Mycoplasma hominis
oligopeptide permease
-
 Mycoplasma hominis
OppA the surface-localised substrate-binding domain OppA of the oligopeptide permease Mycoplasma hominis