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Literature summary for 7.4.2.6 extracted from

  • Lorenzana, L.M.; Perez-Redondo, R.; Santamarta, I.; Martin, J.F.; Liras, P.
    Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor (2004), J. Bacteriol., 186, 3431-3438.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.6

Cloned(Commentary)

Cloned (Comment) Organism
the two genes oppA1 and oppA2 encoding oligopeptide permeases are located in the clavulinic acid cluster, DNA and amino acid sequence determination and analysis Streptomyces clavuligerus

Protein Variants

Protein Variants Comment Organism
additional information generation of disruption mutants of the genes oppA1 or oppA2, the mutant show differing oligopeptide binding and translocation specificity, overview Streptomyces clavuligerus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Streptomyces clavuligerus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + bradykinin/out Streptomyces clavuligerus i.e. RPPGFSPFR, specific for isozyme OppA2 ADP + phosphate + bradykinin/in
-
 ?
ATP + H2O + phosphinotricyl-alanyl-alanine/out Streptomyces clavuligerus import of the toxic tripeptide, isozymes OppA1 and OppA2 ADP + phosphate + phosphinotricyl-alanyl-alanine/in
-
 ?
additional information Streptomyces clavuligerus the two isozymes OppA1 and OppA2 are essential for production of beta-lactamase inhibitor clavulinic acid ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus Q9LCV8 orf7, isozyme oppA1; ATCC 24076, genes oppA1 and oppA2
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Streptomyces clavuligerus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + bradykinin/out i.e. RPPGFSPFR, specific for isozyme OppA2 Streptomyces clavuligerus ADP + phosphate + bradykinin/in
-
 ?
ATP + H2O + bradykinin/out i.e. RPPGFSPFR, specific for isozyme OppA2, ATP hydrolysis is coupled to peptide translocation Streptomyces clavuligerus ADP + phosphate + bradykinin/in
-
 ?
ATP + H2O + phosphinotricyl-alanyl-alanine/out import of the toxic tripeptide, isozymes OppA1 and OppA2 Streptomyces clavuligerus ADP + phosphate + phosphinotricyl-alanyl-alanine/in
-
 ?
ATP + H2O + phosphinotricyl-alanyl-alanine/out a toxic tripeptide, isozymes OppA1 and OppA2, ATP hydrolysis is coupled to peptide translocation Streptomyces clavuligerus ADP + phosphate + phosphinotricyl-alanyl-alanine/in
-
 ?
additional information the two isozymes OppA1 and OppA2 are essential for production of beta-lactamase inhibitor clavulinic acid Streptomyces clavuligerus ?
-
 ?

Synonyms

Synonyms Comment Organism
oligopeptide permease
-
 Streptomyces clavuligerus
OppA
-
 Streptomyces clavuligerus