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Literature summary for 7.4.2.5 extracted from

  • Jensen, J.; Ernst, H.; Wang, X.; Hald, H.; Ditta, A.; Ismat, F.; Rahman, M.; Mirza, O.
    Functional investigation of conserved membrane-embedded glutamate residues in the proton-coupled peptide transporter YjdL (2012), Protein Pept. Lett., 19, 282-287.
    View publication on PubMed
Search for more literature for 7.4.2.5

Protein Variants

Protein Variants Comment Organism
E20D mutant is not affected by the bulk pH in the range tested, no dramatic change in IC50 value for peptides Gly-Lys, beta-Ala-Lys Escherichia coli
E20Q mutant is not affected by the bulk pH in the range tested, no dramatic change in IC50 value for peptides Gly-Lys, beta-Ala-Lys Escherichia coli
E388D increase in IC50 value for peptides Gly-Lys, beta-Ala-Lys, increase in pH-optimum Escherichia coli
E388Q increase in IC50 value for peptides Gly-Lys, beta-Ala-Lys, increase in pH-optimum Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
4-(gamma-aminobutanoyl)-Lys
-
 Escherichia coli
acetyl-Lys
-
 Escherichia coli
beta-Ala-Lys
-
 Escherichia coli
Gly-Lys
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P39276
-
-

Synonyms

Synonyms Comment Organism
dipeptide permease
-
 Escherichia coli
tripeptide permease
-
 Escherichia coli
Yjdl
-
 Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 wild-type Escherichia coli
7 7.5 mutants E388D, E388Q Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 value range between 0.1 and 1 mM for wild-type and E20-mutants, and increase to about 2 mM for mutant E388Q, pH not specified in the publication, temperature not specified in the publication Escherichia coli Gly-Lys
additional information
-
 IC50 value range between 0.1 and 1 mM for wild-type and E20-mutants, and increase to above 10 mM for mutant E388Q, pH not specified in the publication, temperature not specified in the publication Escherichia coli beta-Ala-Lys