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Literature summary for 7.4.2.5 extracted from
- Sap transporter mediated import and subsequent degradation of antimicrobial peptides in Haemophilus (2011), PLoS Pathog., 7, e1002360.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Sap transporter | - |
Haemophilus influenzae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mechanism of Sap-mediated import of antimicrobial peptides, a strategy to reduce periplasmic and inner membrane accumulation of these host defense peptides. Antimicrobial peptides localize to the bacterial cytoplasm of the wild-type strain and are susceptible to cytoplasmic peptidase activity. In bacteria lacking a functional Sap permease complex, antimicrobial peptides accumulate in the periplasm. The periplasmic binding protein SapA binds antimicrobial peptides and is required for virulence in vivo | Haemophilus influenzae |
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